The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.

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Bibliographic Details
Main Authors: Kun Zhang, Xiaohui Han, Zhen Zhang, Lina Zheng, Zhimei Hu, Qingbin Yao, Hongmei Cui, Guiming Shu, Maojie Si, Chan Li, Zhemin Shi, Ting Chen, Yawei Han, Yanan Chang, Zhi Yao, Tao Han, Wei Hong
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/b66f68f91b7c4a3abba46dae2622e5e1
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https://doaj.org/article/b66f68f91b7c4a3abba46dae2622e5e1

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