Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease

The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervou...

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Autores principales:	Doris Chen, Wanjia Yu, Laura Aitken, Frank Gunn-Moore
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Willin/FRMD6 Hippo signaling Alzheimer’s disease neurodegeneration mechanotransduction oxidative stress Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b67184628280410783fae04e19b9810c
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spelling	oai:doaj.org-article:b67184628280410783fae04e19b9810c2021-11-25T17:10:29ZWillin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease10.3390/cells101130242073-4409https://doaj.org/article/b67184628280410783fae04e19b9810c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3024https://doaj.org/toc/2073-4409The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.Doris ChenWanjia YuLaura AitkenFrank Gunn-MooreMDPI AGarticleWillin/FRMD6Hippo signalingAlzheimer’s diseaseneurodegenerationmechanotransductionoxidative stressBiology (General)QH301-705.5ENCells, Vol 10, Iss 3024, p 3024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Willin/FRMD6 Hippo signaling Alzheimer’s disease neurodegeneration mechanotransduction oxidative stress Biology (General) QH301-705.5
spellingShingle	Willin/FRMD6 Hippo signaling Alzheimer’s disease neurodegeneration mechanotransduction oxidative stress Biology (General) QH301-705.5 Doris Chen Wanjia Yu Laura Aitken Frank Gunn-Moore Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
description	The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.
format	article
author	Doris Chen Wanjia Yu Laura Aitken Frank Gunn-Moore
author_facet	Doris Chen Wanjia Yu Laura Aitken Frank Gunn-Moore
author_sort	Doris Chen
title	Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
title_short	Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
title_full	Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
title_fullStr	Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
title_full_unstemmed	Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
title_sort	willin/frmd6: a multi-functional neuronal protein associated with alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b67184628280410783fae04e19b9810c
work_keys_str_mv	AT dorischen willinfrmd6amultifunctionalneuronalproteinassociatedwithalzheimersdisease AT wanjiayu willinfrmd6amultifunctionalneuronalproteinassociatedwithalzheimersdisease AT lauraaitken willinfrmd6amultifunctionalneuronalproteinassociatedwithalzheimersdisease AT frankgunnmoore willinfrmd6amultifunctionalneuronalproteinassociatedwithalzheimersdisease
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Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease

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