Pervasive translational regulation of the cell signalling circuitry underlies mammalian development

Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading...

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Autores principales: Kotaro Fujii, Zhen Shi, Olena Zhulyn, Nicolas Denans, Maria Barna
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b671f96bdcc84d899948f909bb954d03
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Sumario:Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading frames (uORFs).