Pervasive translational regulation of the cell signalling circuitry underlies mammalian development

Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading...

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Autores principales:	Kotaro Fujii, Zhen Shi, Olena Zhulyn, Nicolas Denans, Maria Barna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b671f96bdcc84d899948f909bb954d03
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spelling	oai:doaj.org-article:b671f96bdcc84d899948f909bb954d032021-12-02T14:41:20ZPervasive translational regulation of the cell signalling circuitry underlies mammalian development10.1038/ncomms144432041-1723https://doaj.org/article/b671f96bdcc84d899948f909bb954d032017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14443https://doaj.org/toc/2041-1723Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading frames (uORFs).Kotaro FujiiZhen ShiOlena ZhulynNicolas DenansMaria BarnaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kotaro Fujii Zhen Shi Olena Zhulyn Nicolas Denans Maria Barna Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
description	Gene expression is regulated at several levels, including through the modulation of protein translation. Here the authors find that translation control diversifies gene expression between developing tissues and regulates major signalling pathways through a complex landscape of upstream open reading frames (uORFs).
format	article
author	Kotaro Fujii Zhen Shi Olena Zhulyn Nicolas Denans Maria Barna
author_facet	Kotaro Fujii Zhen Shi Olena Zhulyn Nicolas Denans Maria Barna
author_sort	Kotaro Fujii
title	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
title_short	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
title_full	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
title_fullStr	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
title_full_unstemmed	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development
title_sort	pervasive translational regulation of the cell signalling circuitry underlies mammalian development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b671f96bdcc84d899948f909bb954d03
work_keys_str_mv	AT kotarofujii pervasivetranslationalregulationofthecellsignallingcircuitryunderliesmammaliandevelopment AT zhenshi pervasivetranslationalregulationofthecellsignallingcircuitryunderliesmammaliandevelopment AT olenazhulyn pervasivetranslationalregulationofthecellsignallingcircuitryunderliesmammaliandevelopment AT nicolasdenans pervasivetranslationalregulationofthecellsignallingcircuitryunderliesmammaliandevelopment AT mariabarna pervasivetranslationalregulationofthecellsignallingcircuitryunderliesmammaliandevelopment
_version_	1718389955735060480

Pervasive translational regulation of the cell signalling circuitry underlies mammalian development

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