Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring

Abstract Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy n...

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Autores principales:	Wenli Xu, Ling Yi, Changfei Deng, Ziling Zhao, Longrong Ran, Zhihong Ren, Shunxia Zhao, Tianjin Zhou, Gang Zhang, Hanmin Liu, Li Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6747786be4a4c42a7307b156c9193d4
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spelling	oai:doaj.org-article:b6747786be4a4c42a7307b156c9193d42021-12-02T17:47:15ZMaternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring10.1038/s41598-021-91825-92045-2322https://doaj.org/article/b6747786be4a4c42a7307b156c9193d42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91825-9https://doaj.org/toc/2045-2322Abstract Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP). Unconditional logistic regression analysis was used to estimate the crude and adjusted odds ratios (ORs) and 95% confidential intervals (CI). Significant associations were found between maternal periconceptional FAS and decreased risk of NsCL/P (aOR = 0.41, 95% CI 0.33–0.51). This protective effect was also detected for NsCL (aOR = 0.42, 95% CI 0.30–0.58) and NsCLP (aOR = 0.41, 95% CI 0.31–0.54). Both maternal FAS started before and after the last menstrual period (LMP) were inversely associated with NsCL/P (before LMP, aOR = 0.43, 95% CI 0.33–0.56; after LMP, aOR = 0.41, 95% CI 0.33–0.51). The association between NsCP and maternal FAS initiating before LMP was also found (aOR = 0.52, 95% CI 0.30–0.90). The findings suggest that maternal periconceptional FAS can reduce the risk of each subtype of NsCL/P in offspring, while the potential effect on NsCP needs further investigations.Wenli XuLing YiChangfei DengZiling ZhaoLongrong RanZhihong RenShunxia ZhaoTianjin ZhouGang ZhangHanmin LiuLi DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenli Xu Ling Yi Changfei Deng Ziling Zhao Longrong Ran Zhihong Ren Shunxia Zhao Tianjin Zhou Gang Zhang Hanmin Liu Li Dai Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
description	Abstract Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP). Unconditional logistic regression analysis was used to estimate the crude and adjusted odds ratios (ORs) and 95% confidential intervals (CI). Significant associations were found between maternal periconceptional FAS and decreased risk of NsCL/P (aOR = 0.41, 95% CI 0.33–0.51). This protective effect was also detected for NsCL (aOR = 0.42, 95% CI 0.30–0.58) and NsCLP (aOR = 0.41, 95% CI 0.31–0.54). Both maternal FAS started before and after the last menstrual period (LMP) were inversely associated with NsCL/P (before LMP, aOR = 0.43, 95% CI 0.33–0.56; after LMP, aOR = 0.41, 95% CI 0.33–0.51). The association between NsCP and maternal FAS initiating before LMP was also found (aOR = 0.52, 95% CI 0.30–0.90). The findings suggest that maternal periconceptional FAS can reduce the risk of each subtype of NsCL/P in offspring, while the potential effect on NsCP needs further investigations.
format	article
author	Wenli Xu Ling Yi Changfei Deng Ziling Zhao Longrong Ran Zhihong Ren Shunxia Zhao Tianjin Zhou Gang Zhang Hanmin Liu Li Dai
author_facet	Wenli Xu Ling Yi Changfei Deng Ziling Zhao Longrong Ran Zhihong Ren Shunxia Zhao Tianjin Zhou Gang Zhang Hanmin Liu Li Dai
author_sort	Wenli Xu
title	Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
title_short	Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
title_full	Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
title_fullStr	Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
title_full_unstemmed	Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
title_sort	maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6747786be4a4c42a7307b156c9193d4
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Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring

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