EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE

In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives ar...

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Autores principales:	Diana L. MUÑOZ, Diana P. CARDONA, Álvaro CARDONA, Lina M. CARRILLO, Winston QUIÑONES, Fernando ECHEVERRI, Iván D. VÉLEZ, Sara M. ROBLEDO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/b6764dea1ce9487db792dbb2723ec89b
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spelling	oai:doaj.org-article:b6764dea1ce9487db792dbb2723ec89b2021-11-19T04:22:01ZEFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE0121-40042145-2660https://doaj.org/article/b6764dea1ce9487db792dbb2723ec89b2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/548https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity against Leishmania (V) panamensis but all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds. Diana L. MUÑOZDiana P. CARDONAÁlvaro CARDONALina M. CARRILLOWinston QUIÑONESFernando ECHEVERRIIván D. VÉLEZSara M. ROBLEDOUniversidad de AntioquiaarticleFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 13, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana L. MUÑOZ Diana P. CARDONA Álvaro CARDONA Lina M. CARRILLO Winston QUIÑONES Fernando ECHEVERRI Iván D. VÉLEZ Sara M. ROBLEDO EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
description	In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity against Leishmania (V) panamensis but all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds.
format	article
author	Diana L. MUÑOZ Diana P. CARDONA Álvaro CARDONA Lina M. CARRILLO Winston QUIÑONES Fernando ECHEVERRI Iván D. VÉLEZ Sara M. ROBLEDO
author_facet	Diana L. MUÑOZ Diana P. CARDONA Álvaro CARDONA Lina M. CARRILLO Winston QUIÑONES Fernando ECHEVERRI Iván D. VÉLEZ Sara M. ROBLEDO
author_sort	Diana L. MUÑOZ
title	EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
title_short	EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
title_full	EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
title_fullStr	EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
title_full_unstemmed	EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE
title_sort	effect of hydrazones against intracellular amastigotes of <i>leishmania panamensis</i> and a parasitic cystein protease
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/b6764dea1ce9487db792dbb2723ec89b
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EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE

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