The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells triggers IGF2 secretion and tumourigenesis.

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Autores principales: Hye-Jin Boo, Hye-Young Min, Hyun-Ji Jang, Hye Jeong Yun, John Kendal Smith, Quanri Jin, Hyo-Jong Lee, Diane Liu, Hee-Seok Kweon, Carmen Behrens, J. Jack Lee, Ignacio I. Wistuba, Euni Lee, Waun Ki Hong, Ho-Young Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b677a8e4f78945a8ba09e04a707207e1
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spelling oai:doaj.org-article:b677a8e4f78945a8ba09e04a707207e12021-12-02T16:57:03ZThe tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells10.1038/ncomms129612041-1723https://doaj.org/article/b677a8e4f78945a8ba09e04a707207e12016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12961https://doaj.org/toc/2041-1723The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells triggers IGF2 secretion and tumourigenesis.Hye-Jin BooHye-Young MinHyun-Ji JangHye Jeong YunJohn Kendal SmithQuanri JinHyo-Jong LeeDiane LiuHee-Seok KweonCarmen BehrensJ. Jack LeeIgnacio I. WistubaEuni LeeWaun Ki HongHo-Young LeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hye-Jin Boo
Hye-Young Min
Hyun-Ji Jang
Hye Jeong Yun
John Kendal Smith
Quanri Jin
Hyo-Jong Lee
Diane Liu
Hee-Seok Kweon
Carmen Behrens
J. Jack Lee
Ignacio I. Wistuba
Euni Lee
Waun Ki Hong
Ho-Young Lee
The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
description The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells triggers IGF2 secretion and tumourigenesis.
format article
author Hye-Jin Boo
Hye-Young Min
Hyun-Ji Jang
Hye Jeong Yun
John Kendal Smith
Quanri Jin
Hyo-Jong Lee
Diane Liu
Hee-Seok Kweon
Carmen Behrens
J. Jack Lee
Ignacio I. Wistuba
Euni Lee
Waun Ki Hong
Ho-Young Lee
author_facet Hye-Jin Boo
Hye-Young Min
Hyun-Ji Jang
Hye Jeong Yun
John Kendal Smith
Quanri Jin
Hyo-Jong Lee
Diane Liu
Hee-Seok Kweon
Carmen Behrens
J. Jack Lee
Ignacio I. Wistuba
Euni Lee
Waun Ki Hong
Ho-Young Lee
author_sort Hye-Jin Boo
title The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
title_short The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
title_full The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
title_fullStr The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
title_full_unstemmed The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
title_sort tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via igf2 exocytosis in lung epithelial cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b677a8e4f78945a8ba09e04a707207e1
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