Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Abstract In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b67ac5a436404ece92b369c7af60e330 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b67ac5a436404ece92b369c7af60e330 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b67ac5a436404ece92b369c7af60e3302021-12-02T16:18:02ZIncreased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-1910.1038/s41598-020-78710-72045-2322https://doaj.org/article/b67ac5a436404ece92b369c7af60e3302020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78710-7https://doaj.org/toc/2045-2322Abstract In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2–5 and 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79–0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.Marthe Jøntvedt JørgensenJan Cato HolterErik Egeland ChristensenCamilla SchjalmKristian TonbySøren Erik PischkeSynne JenumLinda G. SkeieSarah NurAndreas LindHanne OpsandTone Burvald EnersenRagnhild GrøndahlAnne HermannSusanne DudmanFredrik MullerThor UelandTom Eirik MollnesPål AukrustLars HeggelundAleksander Rygh HoltenAnne Ma Dyrhol-RiiseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Marthe Jøntvedt Jørgensen Jan Cato Holter Erik Egeland Christensen Camilla Schjalm Kristian Tonby Søren Erik Pischke Synne Jenum Linda G. Skeie Sarah Nur Andreas Lind Hanne Opsand Tone Burvald Enersen Ragnhild Grøndahl Anne Hermann Susanne Dudman Fredrik Muller Thor Ueland Tom Eirik Mollnes Pål Aukrust Lars Heggelund Aleksander Rygh Holten Anne Ma Dyrhol-Riise Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| description |
Abstract In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2–5 and 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79–0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies. |
| format |
article |
| author |
Marthe Jøntvedt Jørgensen Jan Cato Holter Erik Egeland Christensen Camilla Schjalm Kristian Tonby Søren Erik Pischke Synne Jenum Linda G. Skeie Sarah Nur Andreas Lind Hanne Opsand Tone Burvald Enersen Ragnhild Grøndahl Anne Hermann Susanne Dudman Fredrik Muller Thor Ueland Tom Eirik Mollnes Pål Aukrust Lars Heggelund Aleksander Rygh Holten Anne Ma Dyrhol-Riise |
| author_facet |
Marthe Jøntvedt Jørgensen Jan Cato Holter Erik Egeland Christensen Camilla Schjalm Kristian Tonby Søren Erik Pischke Synne Jenum Linda G. Skeie Sarah Nur Andreas Lind Hanne Opsand Tone Burvald Enersen Ragnhild Grøndahl Anne Hermann Susanne Dudman Fredrik Muller Thor Ueland Tom Eirik Mollnes Pål Aukrust Lars Heggelund Aleksander Rygh Holten Anne Ma Dyrhol-Riise |
| author_sort |
Marthe Jøntvedt Jørgensen |
| title |
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| title_short |
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| title_full |
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| title_fullStr |
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| title_full_unstemmed |
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 |
| title_sort |
increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b67ac5a436404ece92b369c7af60e330 |
| work_keys_str_mv |
AT marthejøntvedtjørgensen increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT jancatoholter increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT erikegelandchristensen increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT camillaschjalm increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT kristiantonby increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT sørenerikpischke increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT synnejenum increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT lindagskeie increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT sarahnur increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT andreaslind increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT hanneopsand increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT toneburvaldenersen increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT ragnhildgrøndahl increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT annehermann increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT susannedudman increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT fredrikmuller increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT thorueland increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT tomeirikmollnes increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT palaukrust increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT larsheggelund increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT aleksanderryghholten increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 AT annemadyrholriise increasedinterleukin6andmacrophagechemoattractantprotein1areassociatedwithrespiratoryfailureincovid19 |
| _version_ |
1718384251441774592 |