Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebr...

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Autores principales:	Bai-Shuang Yin, Gao Li, Lian-Jun Fu, Ying Fu, Wan-Li Sha, Guo-Jiang Li, Hong-Bin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	atipamezole telazol xylazine rat c-fos brain Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b67c9cd7c98e4cdc86a35d53dae92feb
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spelling	oai:doaj.org-article:b67c9cd7c98e4cdc86a35d53dae92feb2021-11-17T21:27:51ZAtipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex1820-744810.1515/acve-2016-0042https://doaj.org/article/b67c9cd7c98e4cdc86a35d53dae92feb2016-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0042https://doaj.org/toc/1820-7448The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.Bai-Shuang YinGao LiLian-Jun FuYing FuWan-Li ShaGuo-Jiang LiHong-Bin WangSciendoarticleatipamezoletelazolxylazineratc-fosbrainVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 4, Pp 489-496 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	atipamezole telazol xylazine rat c-fos brain Veterinary medicine SF600-1100
spellingShingle	atipamezole telazol xylazine rat c-fos brain Veterinary medicine SF600-1100 Bai-Shuang Yin Gao Li Lian-Jun Fu Ying Fu Wan-Li Sha Guo-Jiang Li Hong-Bin Wang Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
description	The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.
format	article
author	Bai-Shuang Yin Gao Li Lian-Jun Fu Ying Fu Wan-Li Sha Guo-Jiang Li Hong-Bin Wang
author_facet	Bai-Shuang Yin Gao Li Lian-Jun Fu Ying Fu Wan-Li Sha Guo-Jiang Li Hong-Bin Wang
author_sort	Bai-Shuang Yin
title	Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
title_short	Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
title_full	Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
title_fullStr	Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
title_full_unstemmed	Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex
title_sort	atipamezole attenuated telazol/xylazine-induced expression of c-fos in rat thalamencephal and cerebral cortex
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/b67c9cd7c98e4cdc86a35d53dae92feb
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Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

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