Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the design of non-nucleoside polymerase inhibitors.

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Autores principales:	Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b67e311aac304026b0abe1ca600fda49
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spelling	oai:doaj.org-article:b67e311aac304026b0abe1ca600fda492021-12-02T15:38:41ZCrystal structure of Zika virus NS5 RNA-dependent RNA polymerase10.1038/ncomms147642041-1723https://doaj.org/article/b67e311aac304026b0abe1ca600fda492017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14764https://doaj.org/toc/2041-1723The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the design of non-nucleoside polymerase inhibitors.Andre S. GodoyGustavo M. A. LimaKetllyn I. Z. OliveiraNaiara U. TorresFernando V. MalufRafael V. C. GuidoGlaucius OlivaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andre S. Godoy Gustavo M. A. Lima Ketllyn I. Z. Oliveira Naiara U. Torres Fernando V. Maluf Rafael V. C. Guido Glaucius Oliva Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
description	The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the design of non-nucleoside polymerase inhibitors.
format	article
author	Andre S. Godoy Gustavo M. A. Lima Ketllyn I. Z. Oliveira Naiara U. Torres Fernando V. Maluf Rafael V. C. Guido Glaucius Oliva
author_facet	Andre S. Godoy Gustavo M. A. Lima Ketllyn I. Z. Oliveira Naiara U. Torres Fernando V. Maluf Rafael V. C. Guido Glaucius Oliva
author_sort	Andre S. Godoy
title	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
title_short	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
title_full	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
title_fullStr	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
title_full_unstemmed	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
title_sort	crystal structure of zika virus ns5 rna-dependent rna polymerase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b67e311aac304026b0abe1ca600fda49
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

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