Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide

Despite strong demand for their clinical use, the synthesis of heparin oligosaccharides as anticoagulants remains challenging. Here, a mild and scalable formal synthesis of Fondaparinux pentasaccharide is presented through [Au]/[Ag]-catalyzed glycosidations.

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Autores principales:	Gulab Walke, Niteshlal Kasdekar, Yogesh Sutar, Srinivas Hotha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b6811f823d6b439d9e45f39e05dc7437
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spelling	oai:doaj.org-article:b6811f823d6b439d9e45f39e05dc74372021-12-02T14:21:27ZSilver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide10.1038/s42004-021-00452-y2399-3669https://doaj.org/article/b6811f823d6b439d9e45f39e05dc74372021-02-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00452-yhttps://doaj.org/toc/2399-3669Despite strong demand for their clinical use, the synthesis of heparin oligosaccharides as anticoagulants remains challenging. Here, a mild and scalable formal synthesis of Fondaparinux pentasaccharide is presented through [Au]/[Ag]-catalyzed glycosidations.Gulab WalkeNiteshlal KasdekarYogesh SutarSrinivas HothaNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Gulab Walke Niteshlal Kasdekar Yogesh Sutar Srinivas Hotha Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
description	Despite strong demand for their clinical use, the synthesis of heparin oligosaccharides as anticoagulants remains challenging. Here, a mild and scalable formal synthesis of Fondaparinux pentasaccharide is presented through [Au]/[Ag]-catalyzed glycosidations.
format	article
author	Gulab Walke Niteshlal Kasdekar Yogesh Sutar Srinivas Hotha
author_facet	Gulab Walke Niteshlal Kasdekar Yogesh Sutar Srinivas Hotha
author_sort	Gulab Walke
title	Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
title_short	Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
title_full	Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
title_fullStr	Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
title_full_unstemmed	Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
title_sort	silver-assisted gold-catalyzed formal synthesis of the anticoagulant fondaparinux pentasaccharide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6811f823d6b439d9e45f39e05dc7437
work_keys_str_mv	AT gulabwalke silverassistedgoldcatalyzedformalsynthesisoftheanticoagulantfondaparinuxpentasaccharide AT niteshlalkasdekar silverassistedgoldcatalyzedformalsynthesisoftheanticoagulantfondaparinuxpentasaccharide AT yogeshsutar silverassistedgoldcatalyzedformalsynthesisoftheanticoagulantfondaparinuxpentasaccharide AT srinivashotha silverassistedgoldcatalyzedformalsynthesisoftheanticoagulantfondaparinuxpentasaccharide
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Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide

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