Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice

Abstract Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the cu...

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Autores principales:	William H. Walker II, Jeremy C. Borniger, Surbhi, Abigail A. Zalenski, Stevie L. Muscarella, Julie A. Fitzgerald, Ning Zhang, Monica M. Gaudier-Diaz, A. Courtney DeVries
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b681c1aa1d664a5580c5f4423955cb2b
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spelling	oai:doaj.org-article:b681c1aa1d664a5580c5f4423955cb2b2021-12-02T12:32:05ZMammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice10.1038/s41598-017-07596-92045-2322https://doaj.org/article/b681c1aa1d664a5580c5f4423955cb2b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07596-9https://doaj.org/toc/2045-2322Abstract Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the current study, two cohorts of female Balb/C mice received bilateral orthotopic injections of syngeneic 67NR, 4T07, or 4T1cells (1 × 105 cells per injection) to induce mammary tumors. Approximately three weeks later, learned fear (via fear conditioning) or depressive-like behavior (via tail suspension and forced swim test) was assessed. Proinflammatory cytokine levels were increased in the serum (IL-1β, TNFα, IFNγ) and livers (IL-1β, IL-6, TNFα) of mice with 4T07 or 4T1 tumors compared to 67NR tumors and the vehicle control. IL-1β was increased in both the hippocampus and cortex of mice injected with 4T07 or 4T1 cell lines relative to the other treatment groups. However, mammary tumors had no effect on hippocampal doublecortin + and did not alter depressive-like behavior or learned fear. These data demonstrate that similarly sized tumors can produce differential immune responses and that tumor-induced central pro-inflammatory cytokine production can exist in the absence of depressive-like behavior or cognitive deficits.William H. Walker IIJeremy C. BornigerSurbhiAbigail A. ZalenskiStevie L. MuscarellaJulie A. FitzgeraldNing ZhangMonica M. Gaudier-DiazA. Courtney DeVriesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q William H. Walker II Jeremy C. Borniger Surbhi Abigail A. Zalenski Stevie L. Muscarella Julie A. Fitzgerald Ning Zhang Monica M. Gaudier-Diaz A. Courtney DeVries Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
description	Abstract Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the current study, two cohorts of female Balb/C mice received bilateral orthotopic injections of syngeneic 67NR, 4T07, or 4T1cells (1 × 105 cells per injection) to induce mammary tumors. Approximately three weeks later, learned fear (via fear conditioning) or depressive-like behavior (via tail suspension and forced swim test) was assessed. Proinflammatory cytokine levels were increased in the serum (IL-1β, TNFα, IFNγ) and livers (IL-1β, IL-6, TNFα) of mice with 4T07 or 4T1 tumors compared to 67NR tumors and the vehicle control. IL-1β was increased in both the hippocampus and cortex of mice injected with 4T07 or 4T1 cell lines relative to the other treatment groups. However, mammary tumors had no effect on hippocampal doublecortin + and did not alter depressive-like behavior or learned fear. These data demonstrate that similarly sized tumors can produce differential immune responses and that tumor-induced central pro-inflammatory cytokine production can exist in the absence of depressive-like behavior or cognitive deficits.
format	article
author	William H. Walker II Jeremy C. Borniger Surbhi Abigail A. Zalenski Stevie L. Muscarella Julie A. Fitzgerald Ning Zhang Monica M. Gaudier-Diaz A. Courtney DeVries
author_facet	William H. Walker II Jeremy C. Borniger Surbhi Abigail A. Zalenski Stevie L. Muscarella Julie A. Fitzgerald Ning Zhang Monica M. Gaudier-Diaz A. Courtney DeVries
author_sort	William H. Walker II
title	Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
title_short	Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
title_full	Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
title_fullStr	Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
title_full_unstemmed	Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice
title_sort	mammary tumors induce central pro-inflammatory cytokine expression, but not behavioral deficits in balb/c mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b681c1aa1d664a5580c5f4423955cb2b
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Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice

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