The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

Ubiquitylated proteins are degraded by the proteasome and the three proteasome subunits Rpn10, Rpn13 and Rpn1 recognize ubiquitin chains. Here the authors employ biochemical and kinetic assays and characterise the ubiquitin chain type specificities of these three ubiquitin receptors.

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Autores principales:	Kirby Martinez-Fonts, Caroline Davis, Takuya Tomita, Suzanne Elsasser, Andrew R. Nager, Yuan Shi, Daniel Finley, Andreas Matouschek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6829197ab4442dc88d9ed892b9626e3
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spelling	oai:doaj.org-article:b6829197ab4442dc88d9ed892b9626e32021-12-02T15:39:16ZThe proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates10.1038/s41467-019-13906-82041-1723https://doaj.org/article/b6829197ab4442dc88d9ed892b9626e32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13906-8https://doaj.org/toc/2041-1723Ubiquitylated proteins are degraded by the proteasome and the three proteasome subunits Rpn10, Rpn13 and Rpn1 recognize ubiquitin chains. Here the authors employ biochemical and kinetic assays and characterise the ubiquitin chain type specificities of these three ubiquitin receptors.Kirby Martinez-FontsCaroline DavisTakuya TomitaSuzanne ElsasserAndrew R. NagerYuan ShiDaniel FinleyAndreas MatouschekNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kirby Martinez-Fonts Caroline Davis Takuya Tomita Suzanne Elsasser Andrew R. Nager Yuan Shi Daniel Finley Andreas Matouschek The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
description	Ubiquitylated proteins are degraded by the proteasome and the three proteasome subunits Rpn10, Rpn13 and Rpn1 recognize ubiquitin chains. Here the authors employ biochemical and kinetic assays and characterise the ubiquitin chain type specificities of these three ubiquitin receptors.
format	article
author	Kirby Martinez-Fonts Caroline Davis Takuya Tomita Suzanne Elsasser Andrew R. Nager Yuan Shi Daniel Finley Andreas Matouschek
author_facet	Kirby Martinez-Fonts Caroline Davis Takuya Tomita Suzanne Elsasser Andrew R. Nager Yuan Shi Daniel Finley Andreas Matouschek
author_sort	Kirby Martinez-Fonts
title	The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
title_short	The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
title_full	The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
title_fullStr	The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
title_full_unstemmed	The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
title_sort	proteasome 19s cap and its ubiquitin receptors provide a versatile recognition platform for substrates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6829197ab4442dc88d9ed892b9626e3
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The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

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