The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

Ubiquitylated proteins are degraded by the proteasome and the three proteasome subunits Rpn10, Rpn13 and Rpn1 recognize ubiquitin chains. Here the authors employ biochemical and kinetic assays and characterise the ubiquitin chain type specificities of these three ubiquitin receptors.

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Autores principales: Kirby Martinez-Fonts, Caroline Davis, Takuya Tomita, Suzanne Elsasser, Andrew R. Nager, Yuan Shi, Daniel Finley, Andreas Matouschek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b6829197ab4442dc88d9ed892b9626e3
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