The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

Research and clinical use of circulating cell-free DNA (cirDNA) is expanding rapidly; however, there remain large gaps in our understanding of the influence of lifestyle and biological factors on the amount of cirDNA present in blood. Here, we review 66 individual studies of cirDNA levels and lifest...

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Autores principales:	Nicole Laurencia Yuwono, Kristina Warton, Caroline Elizabeth Ford
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	Circulating cell-free DNA cirDNA biological lifestyle factors plasma Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b683edc190824bd7a4a9b0f135b52a02
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spelling	oai:doaj.org-article:b683edc190824bd7a4a9b0f135b52a022021-11-09T17:30:35ZThe influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma10.7554/eLife.696792050-084Xe69679https://doaj.org/article/b683edc190824bd7a4a9b0f135b52a022021-11-01T00:00:00Zhttps://elifesciences.org/articles/69679https://doaj.org/toc/2050-084XResearch and clinical use of circulating cell-free DNA (cirDNA) is expanding rapidly; however, there remain large gaps in our understanding of the influence of lifestyle and biological factors on the amount of cirDNA present in blood. Here, we review 66 individual studies of cirDNA levels and lifestyle and biological factors, including exercise (acute and chronic), alcohol consumption, occupational hazard exposure, smoking, body mass index, menstruation, hypertension, circadian rhythm, stress, biological sex and age. Despite technical and methodological inconsistences across studies, we identify acute exercise as a significant influence on cirDNA levels. Given the large increase in cirDNA induced by acute exercise, we recommend that controlling for physical activity prior to blood collection is routinely incorporated into study design when total cirDNA levels are of interest. We also highlight appropriate selection and complete reporting of laboratory protocols as important for improving the reproducibility cirDNA studies and ability to critically evaluate the results.Nicole Laurencia YuwonoKristina WartonCaroline Elizabeth FordeLife Sciences Publications LtdarticleCirculating cell-free DNAcirDNAbiologicallifestylefactorsplasmaMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Circulating cell-free DNA cirDNA biological lifestyle factors plasma Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	Circulating cell-free DNA cirDNA biological lifestyle factors plasma Medicine R Science Q Biology (General) QH301-705.5 Nicole Laurencia Yuwono Kristina Warton Caroline Elizabeth Ford The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
description	Research and clinical use of circulating cell-free DNA (cirDNA) is expanding rapidly; however, there remain large gaps in our understanding of the influence of lifestyle and biological factors on the amount of cirDNA present in blood. Here, we review 66 individual studies of cirDNA levels and lifestyle and biological factors, including exercise (acute and chronic), alcohol consumption, occupational hazard exposure, smoking, body mass index, menstruation, hypertension, circadian rhythm, stress, biological sex and age. Despite technical and methodological inconsistences across studies, we identify acute exercise as a significant influence on cirDNA levels. Given the large increase in cirDNA induced by acute exercise, we recommend that controlling for physical activity prior to blood collection is routinely incorporated into study design when total cirDNA levels are of interest. We also highlight appropriate selection and complete reporting of laboratory protocols as important for improving the reproducibility cirDNA studies and ability to critically evaluate the results.
format	article
author	Nicole Laurencia Yuwono Kristina Warton Caroline Elizabeth Ford
author_facet	Nicole Laurencia Yuwono Kristina Warton Caroline Elizabeth Ford
author_sort	Nicole Laurencia Yuwono
title	The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
title_short	The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
title_full	The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
title_fullStr	The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
title_full_unstemmed	The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
title_sort	influence of biological and lifestyle factors on circulating cell-free dna in blood plasma
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/b683edc190824bd7a4a9b0f135b52a02
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The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

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