Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography

Abstract We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retin...

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Autores principales:	Jiyun Lee, Chan Kee Park, Hae-Young Lopilly Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b684b37034d943c49b2d7558f587b20a
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spelling	oai:doaj.org-article:b684b37034d943c49b2d7558f587b20a2021-12-02T16:57:26ZDeterminants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography10.1038/s41598-021-89428-52045-2322https://doaj.org/article/b684b37034d943c49b2d7558f587b20a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89428-5https://doaj.org/toc/2045-2322Abstract We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). The IOP measured at OCTA exam was significantly related to the width of the deep VD (P = 0.009). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (P = 0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse mean deviation (MD) had a significant association with wider superficial VD (P = 0.001, P = 0.003, respectively). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.Jiyun LeeChan Kee ParkHae-Young Lopilly ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiyun Lee Chan Kee Park Hae-Young Lopilly Park Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
description	Abstract We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). The IOP measured at OCTA exam was significantly related to the width of the deep VD (P = 0.009). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (P = 0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse mean deviation (MD) had a significant association with wider superficial VD (P = 0.001, P = 0.003, respectively). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.
format	article
author	Jiyun Lee Chan Kee Park Hae-Young Lopilly Park
author_facet	Jiyun Lee Chan Kee Park Hae-Young Lopilly Park
author_sort	Jiyun Lee
title	Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
title_short	Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
title_full	Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
title_fullStr	Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
title_full_unstemmed	Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
title_sort	determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b684b37034d943c49b2d7558f587b20a
work_keys_str_mv	AT jiyunlee determinantsofvesseldefectsinsuperficialanddeepvascularlayersinnormaltensionglaucomausingopticalcoherencetomographyangiography AT chankeepark determinantsofvesseldefectsinsuperficialanddeepvascularlayersinnormaltensionglaucomausingopticalcoherencetomographyangiography AT haeyounglopillypark determinantsofvesseldefectsinsuperficialanddeepvascularlayersinnormaltensionglaucomausingopticalcoherencetomographyangiography
_version_	1718382586261143552

Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography

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