KRAS regulation by small non-coding RNAs and SNARE proteins

Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagoni...

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Autores principales:	Yonglu Che, Zurab Siprashvili, Joanna R. Kovalski, Tiffany Jiang, Glenn Wozniak, Lara Elcavage, Paul A. Khavari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b685d23387bf46fe8aee5ef2775003e5
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spelling	oai:doaj.org-article:b685d23387bf46fe8aee5ef2775003e52021-12-02T15:36:04ZKRAS regulation by small non-coding RNAs and SNARE proteins10.1038/s41467-019-13106-42041-1723https://doaj.org/article/b685d23387bf46fe8aee5ef2775003e52019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13106-4https://doaj.org/toc/2041-1723Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise these effects.Yonglu CheZurab SiprashviliJoanna R. KovalskiTiffany JiangGlenn WozniakLara ElcavagePaul A. KhavariNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yonglu Che Zurab Siprashvili Joanna R. Kovalski Tiffany Jiang Glenn Wozniak Lara Elcavage Paul A. Khavari KRAS regulation by small non-coding RNAs and SNARE proteins
description	Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise these effects.
format	article
author	Yonglu Che Zurab Siprashvili Joanna R. Kovalski Tiffany Jiang Glenn Wozniak Lara Elcavage Paul A. Khavari
author_facet	Yonglu Che Zurab Siprashvili Joanna R. Kovalski Tiffany Jiang Glenn Wozniak Lara Elcavage Paul A. Khavari
author_sort	Yonglu Che
title	KRAS regulation by small non-coding RNAs and SNARE proteins
title_short	KRAS regulation by small non-coding RNAs and SNARE proteins
title_full	KRAS regulation by small non-coding RNAs and SNARE proteins
title_fullStr	KRAS regulation by small non-coding RNAs and SNARE proteins
title_full_unstemmed	KRAS regulation by small non-coding RNAs and SNARE proteins
title_sort	kras regulation by small non-coding rnas and snare proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b685d23387bf46fe8aee5ef2775003e5
work_keys_str_mv	AT yongluche krasregulationbysmallnoncodingrnasandsnareproteins AT zurabsiprashvili krasregulationbysmallnoncodingrnasandsnareproteins AT joannarkovalski krasregulationbysmallnoncodingrnasandsnareproteins AT tiffanyjiang krasregulationbysmallnoncodingrnasandsnareproteins AT glennwozniak krasregulationbysmallnoncodingrnasandsnareproteins AT laraelcavage krasregulationbysmallnoncodingrnasandsnareproteins AT paulakhavari krasregulationbysmallnoncodingrnasandsnareproteins
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KRAS regulation by small non-coding RNAs and SNARE proteins

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