Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Abstract Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evalu...

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Autores principales:	Anna Prats, Ignacio Martínez-Zalacaín, Beatriz Mothe, Eugènia Negredo, Núria Pérez-Álvarez, Maite Garolera, Sira Domènech-Puigcerver, Pep Coll, Michael Meulbroek, Anna Chamorro, Carmina R. Fumaz, Maria J. Ferrer, Bonaventura Clotet, Carles Soriano-Mas, Jose A. Muñoz-Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b686a287e1084a619c984d1749a54ecd
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spelling	oai:doaj.org-article:b686a287e1084a619c984d1749a54ecd2021-12-02T15:00:14ZEffects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection10.1038/s41598-021-90678-62045-2322https://doaj.org/article/b686a287e1084a619c984d1749a54ecd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90678-6https://doaj.org/toc/2045-2322Abstract Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and > 6 months since estimated date of HIV-1 acquisition (n = 15). We also recruited a group of matched seronegative individuals (n = 15). Assessments were performed at baseline (before initiation of therapy in HIV arms) and at weeks 4 and 48. Baseline cognitive functioning was comparable between the arms. At week 48, we did not find cognitive differences between starting therapy with INSTI earlier than 3 months or later than 6 months after acquisition of HIV-1 infection. Functional status was poorer in individuals diagnosed earlier. This effect recovered 48 weeks after initiation of therapy. Regarding brain imaging, we found that men living with HIV initiating antiretroviral therapy later experienced a greater decrease in medial orbitofrontal cortex over time, with expected negative repercussions for decision-making tasks.Anna PratsIgnacio Martínez-ZalacaínBeatriz MotheEugènia NegredoNúria Pérez-ÁlvarezMaite GaroleraSira Domènech-PuigcerverPep CollMichael MeulbroekAnna ChamorroCarmina R. FumazMaria J. FerrerBonaventura ClotetCarles Soriano-MasJose A. Muñoz-MorenoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Prats Ignacio Martínez-Zalacaín Beatriz Mothe Eugènia Negredo Núria Pérez-Álvarez Maite Garolera Sira Domènech-Puigcerver Pep Coll Michael Meulbroek Anna Chamorro Carmina R. Fumaz Maria J. Ferrer Bonaventura Clotet Carles Soriano-Mas Jose A. Muñoz-Moreno Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
description	Abstract Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and > 6 months since estimated date of HIV-1 acquisition (n = 15). We also recruited a group of matched seronegative individuals (n = 15). Assessments were performed at baseline (before initiation of therapy in HIV arms) and at weeks 4 and 48. Baseline cognitive functioning was comparable between the arms. At week 48, we did not find cognitive differences between starting therapy with INSTI earlier than 3 months or later than 6 months after acquisition of HIV-1 infection. Functional status was poorer in individuals diagnosed earlier. This effect recovered 48 weeks after initiation of therapy. Regarding brain imaging, we found that men living with HIV initiating antiretroviral therapy later experienced a greater decrease in medial orbitofrontal cortex over time, with expected negative repercussions for decision-making tasks.
format	article
author	Anna Prats Ignacio Martínez-Zalacaín Beatriz Mothe Eugènia Negredo Núria Pérez-Álvarez Maite Garolera Sira Domènech-Puigcerver Pep Coll Michael Meulbroek Anna Chamorro Carmina R. Fumaz Maria J. Ferrer Bonaventura Clotet Carles Soriano-Mas Jose A. Muñoz-Moreno
author_facet	Anna Prats Ignacio Martínez-Zalacaín Beatriz Mothe Eugènia Negredo Núria Pérez-Álvarez Maite Garolera Sira Domènech-Puigcerver Pep Coll Michael Meulbroek Anna Chamorro Carmina R. Fumaz Maria J. Ferrer Bonaventura Clotet Carles Soriano-Mas Jose A. Muñoz-Moreno
author_sort	Anna Prats
title	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_short	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_fullStr	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full_unstemmed	Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_sort	effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of hiv-1 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b686a287e1084a619c984d1749a54ecd
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Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

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