Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?

Anastasios Kyriazoglou, 1 Konstantinos Koutsoukos, 1 Flora Zagouri, 1 Michalis Liontos, 1 Efthimios Dimitriadis, 2 Dina Tiniakos, 3, 4 Meletios Athanasios Dimopoulos 1 1Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece; 2Department of Genetics, Agios Savvas Hospital,...

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Autores principales:	Kyriazoglou A, Koutsoukos K, Zagouri F, Liontos M, Dimitriadis E, Tiniakos D, Dimopoulos MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	olaratumab and doxorubicin metastatic hepatic epithelioid hemangioendothelioma 1st line treatment Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b68771081f1d4a1aa43e7c3169c4d690
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spelling	oai:doaj.org-article:b68771081f1d4a1aa43e7c3169c4d6902021-12-02T11:42:38ZMetastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?1178-203Xhttps://doaj.org/article/b68771081f1d4a1aa43e7c3169c4d6902020-02-01T00:00:00Zhttps://www.dovepress.com/metastatic-hepatic-epithelioid-hemangioendothelioma-treated-with-olara-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XAnastasios Kyriazoglou, 1 Konstantinos Koutsoukos, 1 Flora Zagouri, 1 Michalis Liontos, 1 Efthimios Dimitriadis, 2 Dina Tiniakos, 3, 4 Meletios Athanasios Dimopoulos 1 1Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece; 2Department of Genetics, Agios Savvas Hospital, Athens, Greece; 3Department of Pathology Aretaion Hospital, National & Kapodistrian University of Athens, Athens, Greece; 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UKCorrespondence: Anastasios Kyriazoglou Vasilisis Sofias 80, Athens 11528, GreeceTel +302132162545Fax +302132162511Email tassoskyr@gmail.comAbstract: Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.Keywords: Olaratumab and Doxorubicin, metastatic hepatic epithelioid hemangioendothelioma, 1st line treatmentKyriazoglou AKoutsoukos KZagouri FLiontos MDimitriadis ETiniakos DDimopoulos MADove Medical Pressarticleolaratumab and doxorubicinmetastatic hepatic epithelioid hemangioendothelioma1st line treatmentTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 141-146 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	olaratumab and doxorubicin metastatic hepatic epithelioid hemangioendothelioma 1st line treatment Therapeutics. Pharmacology RM1-950
spellingShingle	olaratumab and doxorubicin metastatic hepatic epithelioid hemangioendothelioma 1st line treatment Therapeutics. Pharmacology RM1-950 Kyriazoglou A Koutsoukos K Zagouri F Liontos M Dimitriadis E Tiniakos D Dimopoulos MA Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
description	Anastasios Kyriazoglou, 1 Konstantinos Koutsoukos, 1 Flora Zagouri, 1 Michalis Liontos, 1 Efthimios Dimitriadis, 2 Dina Tiniakos, 3, 4 Meletios Athanasios Dimopoulos 1 1Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece; 2Department of Genetics, Agios Savvas Hospital, Athens, Greece; 3Department of Pathology Aretaion Hospital, National & Kapodistrian University of Athens, Athens, Greece; 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UKCorrespondence: Anastasios Kyriazoglou Vasilisis Sofias 80, Athens 11528, GreeceTel +302132162545Fax +302132162511Email tassoskyr@gmail.comAbstract: Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.Keywords: Olaratumab and Doxorubicin, metastatic hepatic epithelioid hemangioendothelioma, 1st line treatment
format	article
author	Kyriazoglou A Koutsoukos K Zagouri F Liontos M Dimitriadis E Tiniakos D Dimopoulos MA
author_facet	Kyriazoglou A Koutsoukos K Zagouri F Liontos M Dimitriadis E Tiniakos D Dimopoulos MA
author_sort	Kyriazoglou A
title	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_short	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_full	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_fullStr	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_full_unstemmed	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_sort	metastatic hepatic epithelioid hemangioendothelioma treated with olaratumab: a falling star rising?
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b68771081f1d4a1aa43e7c3169c4d690
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Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?

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