Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS

Background: Status epilepticus (SE) is a neurological emergency and is usually associated with significant morbidity and mortality rates. Several clinical scales have been proposed to predict the clinical outcome of such incidents, including the Status Epilepticus Severity Score (STESS), the modifie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tzu-Hsin Huang, Ming-Chi Lai, Yu-Shiue Chen, Chin-Wei Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antiepileptic drugs status epilepticus STESS risk factors score Medicine R
Acceso en línea:	https://doaj.org/article/b68b65f3723a4af88a6408599fe4fe47
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b68b65f3723a4af88a6408599fe4fe47
record_format	dspace
spelling	oai:doaj.org-article:b68b65f3723a4af88a6408599fe4fe472021-11-25T17:46:26ZStatus Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS10.3390/healthcare91115702227-9032https://doaj.org/article/b68b65f3723a4af88a6408599fe4fe472021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1570https://doaj.org/toc/2227-9032Background: Status epilepticus (SE) is a neurological emergency and is usually associated with significant morbidity and mortality rates. Several clinical scales have been proposed to predict the clinical outcome of such incidents, including the Status Epilepticus Severity Score (STESS), the modified STESS (mSTESS), and the Encephalitis-Nonconvulsive Status Epilepticus-Diazepam Resistance-Image Abnormalities-Tracheal intubation (END-IT). Nevertheless, there is still a need for a more practical and precise predictive scale. Methods: This is a retrospective cohort study which examines data from patients with SE in our Department of Neurology between 2009 and 2020. Based on the outcome of each case, the patients were divided into survivor and non-survivor groups. We analyzed the independent factors and adjusted the STESS to achieve a better prediction of prognosis. The predictive accuracy of our new STESS scale was then compared with that of the mSTESS and the END-IT. Results: Data on a total of 59 patients were collected, with 6 of them classified as non-survivors. The effects of the variables of age, sex, underlying disease(s), and type(s) of antiepileptic drug (AED) use showed no significant differences between the survivor and non-survivor groups. Importantly, the number of AEDs used in the first week and the use of thiobarbiturates predicted non-survival. We adjusted the STESS to create the newly modified STESS (nSTESS), which showed a better predictive capacity than the STESS, the mSTESS, and the END-IT. Conclusions: Our adjustment of the STESS with the addition of the factors “number of AEDs within the first week” and “use of thiobarbiturates”, could have a positive impact on the prediction of mortality rates compared with currently used scales. This nSTESS could potentially be useful in clinical practices, for the early prediction of outcomes for patients with SE.Tzu-Hsin HuangMing-Chi LaiYu-Shiue ChenChin-Wei HuangMDPI AGarticleantiepileptic drugsstatus epilepticusSTESSrisk factorsscoreMedicineRENHealthcare, Vol 9, Iss 1570, p 1570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiepileptic drugs status epilepticus STESS risk factors score Medicine R
spellingShingle	antiepileptic drugs status epilepticus STESS risk factors score Medicine R Tzu-Hsin Huang Ming-Chi Lai Yu-Shiue Chen Chin-Wei Huang Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
description	Background: Status epilepticus (SE) is a neurological emergency and is usually associated with significant morbidity and mortality rates. Several clinical scales have been proposed to predict the clinical outcome of such incidents, including the Status Epilepticus Severity Score (STESS), the modified STESS (mSTESS), and the Encephalitis-Nonconvulsive Status Epilepticus-Diazepam Resistance-Image Abnormalities-Tracheal intubation (END-IT). Nevertheless, there is still a need for a more practical and precise predictive scale. Methods: This is a retrospective cohort study which examines data from patients with SE in our Department of Neurology between 2009 and 2020. Based on the outcome of each case, the patients were divided into survivor and non-survivor groups. We analyzed the independent factors and adjusted the STESS to achieve a better prediction of prognosis. The predictive accuracy of our new STESS scale was then compared with that of the mSTESS and the END-IT. Results: Data on a total of 59 patients were collected, with 6 of them classified as non-survivors. The effects of the variables of age, sex, underlying disease(s), and type(s) of antiepileptic drug (AED) use showed no significant differences between the survivor and non-survivor groups. Importantly, the number of AEDs used in the first week and the use of thiobarbiturates predicted non-survival. We adjusted the STESS to create the newly modified STESS (nSTESS), which showed a better predictive capacity than the STESS, the mSTESS, and the END-IT. Conclusions: Our adjustment of the STESS with the addition of the factors “number of AEDs within the first week” and “use of thiobarbiturates”, could have a positive impact on the prediction of mortality rates compared with currently used scales. This nSTESS could potentially be useful in clinical practices, for the early prediction of outcomes for patients with SE.
format	article
author	Tzu-Hsin Huang Ming-Chi Lai Yu-Shiue Chen Chin-Wei Huang
author_facet	Tzu-Hsin Huang Ming-Chi Lai Yu-Shiue Chen Chin-Wei Huang
author_sort	Tzu-Hsin Huang
title	Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
title_short	Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
title_full	Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
title_fullStr	Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
title_full_unstemmed	Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS
title_sort	status epilepticus mortality risk factors and a correlation survey with the newly modified stess
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b68b65f3723a4af88a6408599fe4fe47
work_keys_str_mv	AT tzuhsinhuang statusepilepticusmortalityriskfactorsandacorrelationsurveywiththenewlymodifiedstess AT mingchilai statusepilepticusmortalityriskfactorsandacorrelationsurveywiththenewlymodifiedstess AT yushiuechen statusepilepticusmortalityriskfactorsandacorrelationsurveywiththenewlymodifiedstess AT chinweihuang statusepilepticusmortalityriskfactorsandacorrelationsurveywiththenewlymodifiedstess
_version_	1718412068419272704

Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS

Ejemplares similares