Shared associations identify causal relationships between gene expression and immune cell phenotypes

Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, they find that while many such shared associations...

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Autores principales:	Christiane Gasperi, Sung Chun, Shamil R. Sunyaev, Chris Cotsapas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b68e66cfdaa94729aa5b3c126fb5926d
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spelling	oai:doaj.org-article:b68e66cfdaa94729aa5b3c126fb5926d2021-12-02T13:19:27ZShared associations identify causal relationships between gene expression and immune cell phenotypes10.1038/s42003-021-01823-w2399-3642https://doaj.org/article/b68e66cfdaa94729aa5b3c126fb5926d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01823-whttps://doaj.org/toc/2399-3642Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, they find that while many such shared associations indicate a causal relationship between traits, observation of overlapping genomic associations alone is not sufficient to infer causality.Christiane GasperiSung ChunShamil R. SunyaevChris CotsapasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Christiane Gasperi Sung Chun Shamil R. Sunyaev Chris Cotsapas Shared associations identify causal relationships between gene expression and immune cell phenotypes
description	Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, they find that while many such shared associations indicate a causal relationship between traits, observation of overlapping genomic associations alone is not sufficient to infer causality.
format	article
author	Christiane Gasperi Sung Chun Shamil R. Sunyaev Chris Cotsapas
author_facet	Christiane Gasperi Sung Chun Shamil R. Sunyaev Chris Cotsapas
author_sort	Christiane Gasperi
title	Shared associations identify causal relationships between gene expression and immune cell phenotypes
title_short	Shared associations identify causal relationships between gene expression and immune cell phenotypes
title_full	Shared associations identify causal relationships between gene expression and immune cell phenotypes
title_fullStr	Shared associations identify causal relationships between gene expression and immune cell phenotypes
title_full_unstemmed	Shared associations identify causal relationships between gene expression and immune cell phenotypes
title_sort	shared associations identify causal relationships between gene expression and immune cell phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b68e66cfdaa94729aa5b3c126fb5926d
work_keys_str_mv	AT christianegasperi sharedassociationsidentifycausalrelationshipsbetweengeneexpressionandimmunecellphenotypes AT sungchun sharedassociationsidentifycausalrelationshipsbetweengeneexpressionandimmunecellphenotypes AT shamilrsunyaev sharedassociationsidentifycausalrelationshipsbetweengeneexpressionandimmunecellphenotypes AT chriscotsapas sharedassociationsidentifycausalrelationshipsbetweengeneexpressionandimmunecellphenotypes
_version_	1718393292904726528

Shared associations identify causal relationships between gene expression and immune cell phenotypes

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