Shared associations identify causal relationships between gene expression and immune cell phenotypes
Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, they find that while many such shared associations...
Enregistré dans:
Auteurs principaux: | Christiane Gasperi, Sung Chun, Shamil R. Sunyaev, Chris Cotsapas |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/b68e66cfdaa94729aa5b3c126fb5926d |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
par: Adriaan van der Graaf, et autres
Publié: (2020) -
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
par: Kejun Ying, et autres
Publié: (2021) -
The causal relationship between dyslexia and motion perception reconsidered
par: Sung Jun Joo, et autres
Publié: (2017) -
A differential wiring analysis of expression data correctly identifies the gene containing the causal mutation.
par: Nicholas J Hudson, et autres
Publié: (2009) -
Analyzing causal relationships in proteomic profiles using CausalPath
par: Augustin Luna, et autres
Publié: (2021)