The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores

Abstract Unemployment shocks from the COVID-19 pandemic have reignited concerns over the long-term effects of job loss on population health. Past research has highlighted the corrosive effects of unemployment on health and health behaviors. This study examines whether the effects of job loss on chan...

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Autores principales:	Lauren L. Schmitz, Julia Goodwin, Jiacheng Miao, Qiongshi Lu, Dalton Conley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b68fdef6b7264172a2a34e2f49658892
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spelling	oai:doaj.org-article:b68fdef6b7264172a2a34e2f496588922021-12-02T14:26:51ZThe impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores10.1038/s41598-021-86716-y2045-2322https://doaj.org/article/b68fdef6b7264172a2a34e2f496588922021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86716-yhttps://doaj.org/toc/2045-2322Abstract Unemployment shocks from the COVID-19 pandemic have reignited concerns over the long-term effects of job loss on population health. Past research has highlighted the corrosive effects of unemployment on health and health behaviors. This study examines whether the effects of job loss on changes in body mass index (BMI) are moderated by genetic predisposition using data from the U.S. Health and Retirement Study (HRS). To improve detection of gene-by-environment (G × E) interplay, we interacted layoffs from business closures—a plausibly exogenous environmental exposure—with whole-genome polygenic scores (PGSs) that capture genetic contributions to both the population mean (mPGS) and variance (vPGS) of BMI. Results show evidence of genetic moderation using a vPGS (as opposed to an mPGS) and indicate genome-wide summary measures of phenotypic plasticity may further our understanding of how environmental stimuli modify the distribution of complex traits in a population.Lauren L. SchmitzJulia GoodwinJiacheng MiaoQiongshi LuDalton ConleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lauren L. Schmitz Julia Goodwin Jiacheng Miao Qiongshi Lu Dalton Conley The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
description	Abstract Unemployment shocks from the COVID-19 pandemic have reignited concerns over the long-term effects of job loss on population health. Past research has highlighted the corrosive effects of unemployment on health and health behaviors. This study examines whether the effects of job loss on changes in body mass index (BMI) are moderated by genetic predisposition using data from the U.S. Health and Retirement Study (HRS). To improve detection of gene-by-environment (G × E) interplay, we interacted layoffs from business closures—a plausibly exogenous environmental exposure—with whole-genome polygenic scores (PGSs) that capture genetic contributions to both the population mean (mPGS) and variance (vPGS) of BMI. Results show evidence of genetic moderation using a vPGS (as opposed to an mPGS) and indicate genome-wide summary measures of phenotypic plasticity may further our understanding of how environmental stimuli modify the distribution of complex traits in a population.
format	article
author	Lauren L. Schmitz Julia Goodwin Jiacheng Miao Qiongshi Lu Dalton Conley
author_facet	Lauren L. Schmitz Julia Goodwin Jiacheng Miao Qiongshi Lu Dalton Conley
author_sort	Lauren L. Schmitz
title	The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
title_short	The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
title_full	The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
title_fullStr	The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
title_full_unstemmed	The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores
title_sort	impact of late-career job loss and genetic risk on body mass index: evidence from variance polygenic scores
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b68fdef6b7264172a2a34e2f49658892
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The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores

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