Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to co...

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Autores principales:	Jun Sung Park, Junehawk Lee, Eun Sun Jung, Myeong-Heui Kim, Il Bin Kim, Hyeonju Son, Sangwoo Kim, Sanghyeon Kim, Young Mok Park, Inhee Mook-Jung, Seok Jong Yu, Jeong Ho Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b694e92a879449b6991c1d1dd1d2b943
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spelling	oai:doaj.org-article:b694e92a879449b6991c1d1dd1d2b9432021-12-02T17:02:01ZBrain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation10.1038/s41467-019-11000-72041-1723https://doaj.org/article/b694e92a879449b6991c1d1dd1d2b9432019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11000-7https://doaj.org/toc/2041-1723The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to contribute to phosphorylation and aggregation of tau, including PIN1.Jun Sung ParkJunehawk LeeEun Sun JungMyeong-Heui KimIl Bin KimHyeonju SonSangwoo KimSanghyeon KimYoung Mok ParkInhee Mook-JungSeok Jong YuJeong Ho LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Sung Park Junehawk Lee Eun Sun Jung Myeong-Heui Kim Il Bin Kim Hyeonju Son Sangwoo Kim Sanghyeon Kim Young Mok Park Inhee Mook-Jung Seok Jong Yu Jeong Ho Lee Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
description	The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to contribute to phosphorylation and aggregation of tau, including PIN1.
format	article
author	Jun Sung Park Junehawk Lee Eun Sun Jung Myeong-Heui Kim Il Bin Kim Hyeonju Son Sangwoo Kim Sanghyeon Kim Young Mok Park Inhee Mook-Jung Seok Jong Yu Jeong Ho Lee
author_facet	Jun Sung Park Junehawk Lee Eun Sun Jung Myeong-Heui Kim Il Bin Kim Hyeonju Son Sangwoo Kim Sanghyeon Kim Young Mok Park Inhee Mook-Jung Seok Jong Yu Jeong Ho Lee
author_sort	Jun Sung Park
title	Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
title_short	Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
title_full	Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
title_fullStr	Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
title_full_unstemmed	Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
title_sort	brain somatic mutations observed in alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b694e92a879449b6991c1d1dd1d2b943
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Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

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