HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study

Abstract Our objective was to assess whether human immunodeficiency virus (HIV)-infection directly or indirectly promotes the progression of clinical characteristics of coronary artery disease (CAD). 300 African Americans with asymptomatic CAD (210 male; age: 48.0 ± 7.2 years; 226 HIV-infected) who...

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Autores principales:	Márton Kolossváry, David Celentano, Gary Gerstenblith, David A. Bluemke, Raul N. Mandler, Elliot K. Fishman, Sandeepan Bhatia, Shaoguang Chen, Shenghan Lai, Hong Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6968ff26b8a430db404c836341132a1
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spelling	oai:doaj.org-article:b6968ff26b8a430db404c836341132a12021-12-05T12:14:09ZHIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study10.1038/s41598-021-02556-w2045-2322https://doaj.org/article/b6968ff26b8a430db404c836341132a12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02556-whttps://doaj.org/toc/2045-2322Abstract Our objective was to assess whether human immunodeficiency virus (HIV)-infection directly or indirectly promotes the progression of clinical characteristics of coronary artery disease (CAD). 300 African Americans with asymptomatic CAD (210 male; age: 48.0 ± 7.2 years; 226 HIV-infected) who underwent coronary CT angiography at two time points (mean follow-up: 4.0 ± 2.3 years) were randomly selected from 1429 participants of a prospective epidemiological study between May 2004 and August 2015. We calculated Agatston-scores, number of coronary plaques and segment stenosis score (SSS). Linear mixed models were used to assess the effects of HIV-infection, atherosclerotic cardiovascular disease (ASCVD) risk, years of cocaine use on CAD. There was no significant difference in annual progression rates between HIV-infected and—uninfected regarding Agatston-scores (10.8 ± 25.1/year vs. 7.2 ± 17.8/year, p = 0.17), the number of plaques (0.2 ± 0.3/year vs. 0.3 ± 0.5/year, p = 0.11) or SSS (0.5 ± 0.8/year vs. 0.5 ± 1.3/year, p = 0.96). Multivariately, HIV-infection was not associated with Agatston-scores (8.3, CI: [− 37.2–53.7], p = 0.72), the number of coronary plaques (− 0.1, CI: [− 0.5–0.4], p = 0.73) or SSS (− 0.1, CI: [− 1.0–0.8], p = 0.84). ASCVD risk scores and years of cocaine-use significantly increased all CAD outcomes among HIV-infected individuals, but not among HIV-uninfected. Importantly, none of the HIV-medications were associated with any of the CAD outcomes. HIV-infection is not directly associated with CAD and therefore HIV-infected are not destined to have worse CAD profiles. However, HIV-infection may indirectly promote CAD progression as risk factors may have a more prominent role in the acceleration of CAD in these patients.Márton KolossváryDavid CelentanoGary GerstenblithDavid A. BluemkeRaul N. MandlerElliot K. FishmanSandeepan BhatiaShaoguang ChenShenghan LaiHong LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Márton Kolossváry David Celentano Gary Gerstenblith David A. Bluemke Raul N. Mandler Elliot K. Fishman Sandeepan Bhatia Shaoguang Chen Shenghan Lai Hong Lai HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
description	Abstract Our objective was to assess whether human immunodeficiency virus (HIV)-infection directly or indirectly promotes the progression of clinical characteristics of coronary artery disease (CAD). 300 African Americans with asymptomatic CAD (210 male; age: 48.0 ± 7.2 years; 226 HIV-infected) who underwent coronary CT angiography at two time points (mean follow-up: 4.0 ± 2.3 years) were randomly selected from 1429 participants of a prospective epidemiological study between May 2004 and August 2015. We calculated Agatston-scores, number of coronary plaques and segment stenosis score (SSS). Linear mixed models were used to assess the effects of HIV-infection, atherosclerotic cardiovascular disease (ASCVD) risk, years of cocaine use on CAD. There was no significant difference in annual progression rates between HIV-infected and—uninfected regarding Agatston-scores (10.8 ± 25.1/year vs. 7.2 ± 17.8/year, p = 0.17), the number of plaques (0.2 ± 0.3/year vs. 0.3 ± 0.5/year, p = 0.11) or SSS (0.5 ± 0.8/year vs. 0.5 ± 1.3/year, p = 0.96). Multivariately, HIV-infection was not associated with Agatston-scores (8.3, CI: [− 37.2–53.7], p = 0.72), the number of coronary plaques (− 0.1, CI: [− 0.5–0.4], p = 0.73) or SSS (− 0.1, CI: [− 1.0–0.8], p = 0.84). ASCVD risk scores and years of cocaine-use significantly increased all CAD outcomes among HIV-infected individuals, but not among HIV-uninfected. Importantly, none of the HIV-medications were associated with any of the CAD outcomes. HIV-infection is not directly associated with CAD and therefore HIV-infected are not destined to have worse CAD profiles. However, HIV-infection may indirectly promote CAD progression as risk factors may have a more prominent role in the acceleration of CAD in these patients.
format	article
author	Márton Kolossváry David Celentano Gary Gerstenblith David A. Bluemke Raul N. Mandler Elliot K. Fishman Sandeepan Bhatia Shaoguang Chen Shenghan Lai Hong Lai
author_facet	Márton Kolossváry David Celentano Gary Gerstenblith David A. Bluemke Raul N. Mandler Elliot K. Fishman Sandeepan Bhatia Shaoguang Chen Shenghan Lai Hong Lai
author_sort	Márton Kolossváry
title	HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
title_short	HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
title_full	HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
title_fullStr	HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
title_full_unstemmed	HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
title_sort	hiv indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6968ff26b8a430db404c836341132a1
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HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study

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