Mining nematode protein secretomes to explain lifestyle and host specificity.

Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partl...

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Autores principales:	Lucienne Tritten, Cristina Ballesteros, Robin Beech, Timothy G Geary, Yovany Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b69745fa329f4bf79a314a4a95810598
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spelling	oai:doaj.org-article:b69745fa329f4bf79a314a4a958105982021-12-02T20:24:00ZMining nematode protein secretomes to explain lifestyle and host specificity.1935-27271935-273510.1371/journal.pntd.0009828https://doaj.org/article/b69745fa329f4bf79a314a4a958105982021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009828https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partly achieved through the release of excretory/secretory proteins, the most well-characterized component of nematode secretomes, that are comprised of functionally diverse molecules. In this work, we analyzed published protein secretomes of parasitic nematodes to identify common patterns as well as species-specific traits. The 20 selected organisms span 4 nematode clades, including plant pathogens, animal parasites, and the free-living species Caenorhabditis elegans. Transthyretin-like proteins were the only component common to all adult secretomes; many other protein classes overlapped across multiple datasets. The glycolytic enzymes aldolase and enolase were present in all parasitic species, but missing from C. elegans. Secretomes from larval stages showed less overlap between species. Although comparison of secretome composition across species and life-cycle stages is challenged by the use of different methods and depths of sequencing among studies, our workflow enabled the identification of conserved protein families and pinpointed elements that may have evolved as to enable parasitism. This strategy, extended to more secretomes, may be exploited to prioritize therapeutic targets in the future.Lucienne TrittenCristina BallesterosRobin BeechTimothy G GearyYovany MorenoPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009828 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno Mining nematode protein secretomes to explain lifestyle and host specificity.
description	Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partly achieved through the release of excretory/secretory proteins, the most well-characterized component of nematode secretomes, that are comprised of functionally diverse molecules. In this work, we analyzed published protein secretomes of parasitic nematodes to identify common patterns as well as species-specific traits. The 20 selected organisms span 4 nematode clades, including plant pathogens, animal parasites, and the free-living species Caenorhabditis elegans. Transthyretin-like proteins were the only component common to all adult secretomes; many other protein classes overlapped across multiple datasets. The glycolytic enzymes aldolase and enolase were present in all parasitic species, but missing from C. elegans. Secretomes from larval stages showed less overlap between species. Although comparison of secretome composition across species and life-cycle stages is challenged by the use of different methods and depths of sequencing among studies, our workflow enabled the identification of conserved protein families and pinpointed elements that may have evolved as to enable parasitism. This strategy, extended to more secretomes, may be exploited to prioritize therapeutic targets in the future.
format	article
author	Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno
author_facet	Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno
author_sort	Lucienne Tritten
title	Mining nematode protein secretomes to explain lifestyle and host specificity.
title_short	Mining nematode protein secretomes to explain lifestyle and host specificity.
title_full	Mining nematode protein secretomes to explain lifestyle and host specificity.
title_fullStr	Mining nematode protein secretomes to explain lifestyle and host specificity.
title_full_unstemmed	Mining nematode protein secretomes to explain lifestyle and host specificity.
title_sort	mining nematode protein secretomes to explain lifestyle and host specificity.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b69745fa329f4bf79a314a4a95810598
work_keys_str_mv	AT luciennetritten miningnematodeproteinsecretomestoexplainlifestyleandhostspecificity AT cristinaballesteros miningnematodeproteinsecretomestoexplainlifestyleandhostspecificity AT robinbeech miningnematodeproteinsecretomestoexplainlifestyleandhostspecificity AT timothyggeary miningnematodeproteinsecretomestoexplainlifestyleandhostspecificity AT yovanymoreno miningnematodeproteinsecretomestoexplainlifestyleandhostspecificity
_version_	1718374126836514816

Mining nematode protein secretomes to explain lifestyle and host specificity.

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