Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.

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Auteurs principaux:	Yeonjoo Kim, Jiyoung Lee, Maisa Seppala, Martyn T. Cobourne, Soo-Hyun Kim
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b4
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id	oai:doaj.org-article:b69b8936bb0c4d058f0730effc0b83b4
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spelling	oai:doaj.org-article:b69b8936bb0c4d058f0730effc0b83b42021-12-02T17:31:24ZPtch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration10.1038/s41467-020-15897-32041-1723https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b42020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15897-3https://doaj.org/toc/2041-1723How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.Yeonjoo KimJiyoung LeeMaisa SeppalaMartyn T. CobourneSoo-Hyun KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
description	How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.
format	article
author	Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim
author_facet	Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim
author_sort	Yeonjoo Kim
title	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_short	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_full	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_fullStr	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_full_unstemmed	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_sort	ptch2/gas1 and ptch1/boc differentially regulate hedgehog signalling in murine primordial germ cell migration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b4
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Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

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