Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.
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Nature Portfolio
2020
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oai:doaj.org-article:b69b8936bb0c4d058f0730effc0b83b42021-12-02T17:31:24ZPtch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration10.1038/s41467-020-15897-32041-1723https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b42020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15897-3https://doaj.org/toc/2041-1723How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.Yeonjoo KimJiyoung LeeMaisa SeppalaMartyn T. CobourneSoo-Hyun KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
description |
How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells. |
format |
article |
author |
Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim |
author_facet |
Yeonjoo Kim Jiyoung Lee Maisa Seppala Martyn T. Cobourne Soo-Hyun Kim |
author_sort |
Yeonjoo Kim |
title |
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
title_short |
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
title_full |
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
title_fullStr |
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
title_full_unstemmed |
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration |
title_sort |
ptch2/gas1 and ptch1/boc differentially regulate hedgehog signalling in murine primordial germ cell migration |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b4 |
work_keys_str_mv |
AT yeonjookim ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration AT jiyounglee ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration AT maisaseppala ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration AT martyntcobourne ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration AT soohyunkim ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration |
_version_ |
1718380634519371776 |