Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.

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Autores principales: Yeonjoo Kim, Jiyoung Lee, Maisa Seppala, Martyn T. Cobourne, Soo-Hyun Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b4
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spelling oai:doaj.org-article:b69b8936bb0c4d058f0730effc0b83b42021-12-02T17:31:24ZPtch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration10.1038/s41467-020-15897-32041-1723https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b42020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15897-3https://doaj.org/toc/2041-1723How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.Yeonjoo KimJiyoung LeeMaisa SeppalaMartyn T. CobourneSoo-Hyun KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yeonjoo Kim
Jiyoung Lee
Maisa Seppala
Martyn T. Cobourne
Soo-Hyun Kim
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
description How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.
format article
author Yeonjoo Kim
Jiyoung Lee
Maisa Seppala
Martyn T. Cobourne
Soo-Hyun Kim
author_facet Yeonjoo Kim
Jiyoung Lee
Maisa Seppala
Martyn T. Cobourne
Soo-Hyun Kim
author_sort Yeonjoo Kim
title Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_short Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_full Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_fullStr Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_full_unstemmed Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
title_sort ptch2/gas1 and ptch1/boc differentially regulate hedgehog signalling in murine primordial germ cell migration
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b69b8936bb0c4d058f0730effc0b83b4
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AT maisaseppala ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration
AT martyntcobourne ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration
AT soohyunkim ptch2gas1andptch1bocdifferentiallyregulatehedgehogsignallinginmurineprimordialgermcellmigration
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