Sources of bias in genetic association studies of cattle: a review

Background: Genetic association studies have been increasingly used in cattle breeding programs. However, inconsistent results -such as positive, negative, or absence of association- across studies restrain reproducibility and proper implementation, propitiating the occurrence of bias. Objective: To...

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Autores principales:	José L. Zepeda Batista, María I. Carrillo Díaz, Luis A. Saavedra Jiménez
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2018
Materias:	association estimates genetic bias genetic improvement sampling-related bias statistical bias Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/b6a1acff82d04f0cbef365d156f07ae2
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spelling	oai:doaj.org-article:b6a1acff82d04f0cbef365d156f07ae22021-12-01T19:35:10ZSources of bias in genetic association studies of cattle: a review2256-295810.17533/udea.rccp.v31n4a02https://doaj.org/article/b6a1acff82d04f0cbef365d156f07ae22018-12-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/rccp/article/view/332927https://doaj.org/toc/2256-2958Background: Genetic association studies have been increasingly used in cattle breeding programs. However, inconsistent results -such as positive, negative, or absence of association- across studies restrain reproducibility and proper implementation, propitiating the occurrence of bias. Objective: To identify and classify potential sources of bias and determine possible strategies to avoid it in genetic association studies in cattle. Source of bias in genetic association studies: Genetic and genomic sources of bias include effects associated with the gene loci governing expression. Sampling-related and statistical biases are related with factors such as stratification and database size. Strategies to correct bias in genetic association studies: Correction strategies differ in nature. Genetic and genomic strategies are based on determining the appropriate approach to obtain and report the genetic information. Sampling-related and statistical strategies are based on grouping individuals with certain traits that lead to a reduction in heterogeneity. Conclusion: It is necessary to consider the methodology used in previous studies to establish a hierarchy of sources of bias and facilitate decisions on the use of tools to reduce inconsistencies in the results of future studies.José L. Zepeda BatistaMaría I. Carrillo DíazLuis A. Saavedra JiménezUniversidad de Antioquiaarticleassociation estimatesgenetic biasgenetic improvementsampling-related biasstatistical biasAnimal cultureSF1-1100ENRevista Colombiana de Ciencias Pecuarias, Vol 31, Iss 4, Pp 256-266 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	association estimates genetic bias genetic improvement sampling-related bias statistical bias Animal culture SF1-1100
spellingShingle	association estimates genetic bias genetic improvement sampling-related bias statistical bias Animal culture SF1-1100 José L. Zepeda Batista María I. Carrillo Díaz Luis A. Saavedra Jiménez Sources of bias in genetic association studies of cattle: a review
description	Background: Genetic association studies have been increasingly used in cattle breeding programs. However, inconsistent results -such as positive, negative, or absence of association- across studies restrain reproducibility and proper implementation, propitiating the occurrence of bias. Objective: To identify and classify potential sources of bias and determine possible strategies to avoid it in genetic association studies in cattle. Source of bias in genetic association studies: Genetic and genomic sources of bias include effects associated with the gene loci governing expression. Sampling-related and statistical biases are related with factors such as stratification and database size. Strategies to correct bias in genetic association studies: Correction strategies differ in nature. Genetic and genomic strategies are based on determining the appropriate approach to obtain and report the genetic information. Sampling-related and statistical strategies are based on grouping individuals with certain traits that lead to a reduction in heterogeneity. Conclusion: It is necessary to consider the methodology used in previous studies to establish a hierarchy of sources of bias and facilitate decisions on the use of tools to reduce inconsistencies in the results of future studies.
format	article
author	José L. Zepeda Batista María I. Carrillo Díaz Luis A. Saavedra Jiménez
author_facet	José L. Zepeda Batista María I. Carrillo Díaz Luis A. Saavedra Jiménez
author_sort	José L. Zepeda Batista
title	Sources of bias in genetic association studies of cattle: a review
title_short	Sources of bias in genetic association studies of cattle: a review
title_full	Sources of bias in genetic association studies of cattle: a review
title_fullStr	Sources of bias in genetic association studies of cattle: a review
title_full_unstemmed	Sources of bias in genetic association studies of cattle: a review
title_sort	sources of bias in genetic association studies of cattle: a review
publisher	Universidad de Antioquia
publishDate	2018
url	https://doaj.org/article/b6a1acff82d04f0cbef365d156f07ae2
work_keys_str_mv	AT joselzepedabatista sourcesofbiasingeneticassociationstudiesofcattleareview AT mariaicarrillodiaz sourcesofbiasingeneticassociationstudiesofcattleareview AT luisasaavedrajimenez sourcesofbiasingeneticassociationstudiesofcattleareview
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Sources of bias in genetic association studies of cattle: a review

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