Resting-state functional heterogeneity of the right insula contributes to pain sensitivity

Abstract Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we...

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Autores principales:	Dániel Veréb, Bálint Kincses, Tamás Spisák, Frederik Schlitt, Nikoletta Szabó, Péter Faragó, Krisztián Kocsis, Bence Bozsik, Eszter Tóth, András Király, Matthias Zunhammer, Tobias Schmidt-Wilcke, Ulrike Bingel, Zsigmond Tamás Kincses
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6a29b7b55b5424481879455ffcbb6e3
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spelling	oai:doaj.org-article:b6a29b7b55b5424481879455ffcbb6e32021-11-28T12:20:14ZResting-state functional heterogeneity of the right insula contributes to pain sensitivity10.1038/s41598-021-02474-x2045-2322https://doaj.org/article/b6a29b7b55b5424481879455ffcbb6e32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02474-xhttps://doaj.org/toc/2045-2322Abstract Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we included 107 healthy participants, who underwent resting state functional MRI scans, T1-weighted scans and quantitative sensory testing on the left forearm. Thermal and mechanical pain thresholds were determined. Connectopic mapping, a technique using non-linear representations of functional organization was employed to describe functional connectivity gradients in both insulae. Partial coefficients of determination were calculated between trend surface model parameters summarizing spatial features of gradients, modal and modality-independent pain sensitivity. The dominant connectopy captured the previously reported posteroanterior shift in connectivity profiles. Spatial features of dominant connectopies in the right insula explained significant amounts of variance in thermal (R2 = 0.076; p < 0.001 and R2 = 0.031; p < 0.029) and composite pain sensitivity (R2 = 0.072; p < 0.002). The left insular gradient was not significantly associated with pain thresholds. Our results highlight the functional relevance of gradient-like insular organization in pain processing. Considering individual variations in insular connectopy might contribute to understanding neural mechanisms behind pain and improve objective brain-based characterization of individual pain sensitivity.Dániel VerébBálint KincsesTamás SpisákFrederik SchlittNikoletta SzabóPéter FaragóKrisztián KocsisBence BozsikEszter TóthAndrás KirályMatthias ZunhammerTobias Schmidt-WilckeUlrike BingelZsigmond Tamás KincsesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dániel Veréb Bálint Kincses Tamás Spisák Frederik Schlitt Nikoletta Szabó Péter Faragó Krisztián Kocsis Bence Bozsik Eszter Tóth András Király Matthias Zunhammer Tobias Schmidt-Wilcke Ulrike Bingel Zsigmond Tamás Kincses Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
description	Abstract Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we included 107 healthy participants, who underwent resting state functional MRI scans, T1-weighted scans and quantitative sensory testing on the left forearm. Thermal and mechanical pain thresholds were determined. Connectopic mapping, a technique using non-linear representations of functional organization was employed to describe functional connectivity gradients in both insulae. Partial coefficients of determination were calculated between trend surface model parameters summarizing spatial features of gradients, modal and modality-independent pain sensitivity. The dominant connectopy captured the previously reported posteroanterior shift in connectivity profiles. Spatial features of dominant connectopies in the right insula explained significant amounts of variance in thermal (R2 = 0.076; p < 0.001 and R2 = 0.031; p < 0.029) and composite pain sensitivity (R2 = 0.072; p < 0.002). The left insular gradient was not significantly associated with pain thresholds. Our results highlight the functional relevance of gradient-like insular organization in pain processing. Considering individual variations in insular connectopy might contribute to understanding neural mechanisms behind pain and improve objective brain-based characterization of individual pain sensitivity.
format	article
author	Dániel Veréb Bálint Kincses Tamás Spisák Frederik Schlitt Nikoletta Szabó Péter Faragó Krisztián Kocsis Bence Bozsik Eszter Tóth András Király Matthias Zunhammer Tobias Schmidt-Wilcke Ulrike Bingel Zsigmond Tamás Kincses
author_facet	Dániel Veréb Bálint Kincses Tamás Spisák Frederik Schlitt Nikoletta Szabó Péter Faragó Krisztián Kocsis Bence Bozsik Eszter Tóth András Király Matthias Zunhammer Tobias Schmidt-Wilcke Ulrike Bingel Zsigmond Tamás Kincses
author_sort	Dániel Veréb
title	Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
title_short	Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
title_full	Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
title_fullStr	Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
title_full_unstemmed	Resting-state functional heterogeneity of the right insula contributes to pain sensitivity
title_sort	resting-state functional heterogeneity of the right insula contributes to pain sensitivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6a29b7b55b5424481879455ffcbb6e3
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Resting-state functional heterogeneity of the right insula contributes to pain sensitivity

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