Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China

Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnose...

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Autores principales:	JiaoJiao Lu, Jing Yang, WenXu Dong, BaoJia Tang, LuoYuan Cao, YingHua Lin, BaoYing Huang, XianGuo Fu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	ankylosing spondylitis high‐resolution PCR‐SSP HLA‐B*27 subtypes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b6a430af74ce4015b6abbc8b20b8f832
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spelling	oai:doaj.org-article:b6a430af74ce4015b6abbc8b20b8f8322021-11-12T19:57:15ZPredominant frequency of HLA‐B27 in patients with ankylosing spondylitis in southeastern China2050-452710.1002/iid3.524https://doaj.org/article/b6a430af74ce4015b6abbc8b20b8f8322021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.524https://doaj.org/toc/2050-4527Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high‐resolution PCR‐SSP.Exon 2‐3 of HLA‐B27 gene was amplified and sequenced to further confirm the HLA‐B27 subtype. Results The frequency of HLA‐B27 was 99.87% in AS patients. Three subtypes, HLA‐B2704, HLA‐B2705, and HLA‐B2706 were identified. The frequencies for these three alleles were HLA‐B2704 in 84/88 (95.46%), HLA‐B2705 in 3/88(3.41%), and HLA‐B2706 in 1/88 (1.13%) of the HLA‐B27 positive patients, respectively. Conclusions Our study shows that HLA‐B2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA‐B27‐subtype distributions in Chinese Han populations showed that HLA‐B2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA‐B2705 show the opposite result.JiaoJiao LuJing YangWenXu DongBaoJia TangLuoYuan CaoYingHua LinBaoYing HuangXianGuo FuWileyarticleankylosing spondylitishigh‐resolution PCR‐SSPHLA‐B*27subtypesImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1696-1701 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ankylosing spondylitis high‐resolution PCR‐SSP HLA‐B*27 subtypes Immunologic diseases. Allergy RC581-607
spellingShingle	ankylosing spondylitis high‐resolution PCR‐SSP HLA‐B27 subtypes Immunologic diseases. Allergy RC581-607 JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu Predominant frequency of HLA‐B27 in patients with ankylosing spondylitis in southeastern China
description	Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high‐resolution PCR‐SSP.Exon 2‐3 of HLA‐B27 gene was amplified and sequenced to further confirm the HLA‐B27 subtype. Results The frequency of HLA‐B27 was 99.87% in AS patients. Three subtypes, HLA‐B2704, HLA‐B2705, and HLA‐B2706 were identified. The frequencies for these three alleles were HLA‐B2704 in 84/88 (95.46%), HLA‐B2705 in 3/88(3.41%), and HLA‐B2706 in 1/88 (1.13%) of the HLA‐B27 positive patients, respectively. Conclusions Our study shows that HLA‐B2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA‐B27‐subtype distributions in Chinese Han populations showed that HLA‐B2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA‐B*2705 show the opposite result.
format	article
author	JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu
author_facet	JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu
author_sort	JiaoJiao Lu
title	Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
title_short	Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
title_full	Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
title_fullStr	Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
title_full_unstemmed	Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
title_sort	predominant frequency of hla‐b*27 in patients with ankylosing spondylitis in southeastern china
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b6a430af74ce4015b6abbc8b20b8f832
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_version_	1718430338585198592

Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China

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