Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions

Abstract Drug-related problems (DRP) cause preventable negative health outcomes, especially during hospital admissions. The aim of our study was to examine the prevalence and characteristics of DRP in regular clinical pharmacy, as well as to determine those factors associated with a higher risk of D...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Noe Garin, Nuria Sole, Beatriz Lucas, Laia Matas, Desiree Moras, Ana Rodrigo-Troyano, Laura Gras-Martin, Nuria Fonts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6a5f88d587a4d9a9d048ce4f240558b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b6a5f88d587a4d9a9d048ce4f240558b
record_format	dspace
spelling	oai:doaj.org-article:b6a5f88d587a4d9a9d048ce4f240558b2021-12-02T14:01:21ZDrug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions10.1038/s41598-020-80560-22045-2322https://doaj.org/article/b6a5f88d587a4d9a9d048ce4f240558b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80560-2https://doaj.org/toc/2045-2322Abstract Drug-related problems (DRP) cause preventable negative health outcomes, especially during hospital admissions. The aim of our study was to examine the prevalence and characteristics of DRP in regular clinical pharmacy, as well as to determine those factors associated with a higher risk of DRP in the hospital setting. We analyzed data from a standardized registry database of regular pharmacy practice (2015- 2016). DRP were classified according to the Pharmaceutical Care Network Europe v6.2 classification. Cross-sectional data were obtained from 1602 adults admitted to medical wards. Crude and adjusted binary logistic regressions were performed to identify associations between potential risk factors and DRP. Overall DRP prevalence was high across medical specialties (45,1%), in a population characterized by advanced age, polypharmacy and multimorbidity. Problems leading to DRP were mainly classified into two domains (effectiveness and adverse reactions), being drug and dose selection the most frequent causes. Interventions were accepted and DRP were totally or partially solved in 74.1% and 4.81% of cases, respectively. In the adjusted model polypharmacy, allergies, BMI > 25 kg/m2 and clearance < 30 mL/min were associated with a higher risk of DRP. The participation of clinical pharmacists into multidisciplinary teams promotes the detection and solution of DRP. Polypharmacy, obesity, renal impairment and allergy are associated with a higher risk of DRP during admission.Noe GarinNuria SoleBeatriz LucasLaia MatasDesiree MorasAna Rodrigo-TroyanoLaura Gras-MartinNuria FontsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noe Garin Nuria Sole Beatriz Lucas Laia Matas Desiree Moras Ana Rodrigo-Troyano Laura Gras-Martin Nuria Fonts Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
description	Abstract Drug-related problems (DRP) cause preventable negative health outcomes, especially during hospital admissions. The aim of our study was to examine the prevalence and characteristics of DRP in regular clinical pharmacy, as well as to determine those factors associated with a higher risk of DRP in the hospital setting. We analyzed data from a standardized registry database of regular pharmacy practice (2015- 2016). DRP were classified according to the Pharmaceutical Care Network Europe v6.2 classification. Cross-sectional data were obtained from 1602 adults admitted to medical wards. Crude and adjusted binary logistic regressions were performed to identify associations between potential risk factors and DRP. Overall DRP prevalence was high across medical specialties (45,1%), in a population characterized by advanced age, polypharmacy and multimorbidity. Problems leading to DRP were mainly classified into two domains (effectiveness and adverse reactions), being drug and dose selection the most frequent causes. Interventions were accepted and DRP were totally or partially solved in 74.1% and 4.81% of cases, respectively. In the adjusted model polypharmacy, allergies, BMI > 25 kg/m2 and clearance < 30 mL/min were associated with a higher risk of DRP. The participation of clinical pharmacists into multidisciplinary teams promotes the detection and solution of DRP. Polypharmacy, obesity, renal impairment and allergy are associated with a higher risk of DRP during admission.
format	article
author	Noe Garin Nuria Sole Beatriz Lucas Laia Matas Desiree Moras Ana Rodrigo-Troyano Laura Gras-Martin Nuria Fonts
author_facet	Noe Garin Nuria Sole Beatriz Lucas Laia Matas Desiree Moras Ana Rodrigo-Troyano Laura Gras-Martin Nuria Fonts
author_sort	Noe Garin
title	Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
title_short	Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
title_full	Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
title_fullStr	Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
title_full_unstemmed	Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
title_sort	drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6a5f88d587a4d9a9d048ce4f240558b
work_keys_str_mv	AT noegarin drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT nuriasole drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT beatrizlucas drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT laiamatas drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT desireemoras drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT anarodrigotroyano drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT lauragrasmartin drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions AT nuriafonts drugrelatedproblemsinclinicalpracticeacrosssectionalstudyontheirprevalenceriskfactorsandassociatedpharmaceuticalinterventions
_version_	1718392222819287040

Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions

Ejemplares similares