Growth hormone and aging: A challenging controversy

Andrzej BartkeGeriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH...

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Autor principal:	Andrzej Bartke
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Growth hormone longevity cancer anti-aging therapies mutant mice Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b6a62a8ee06f40d49a62f7a988887e55
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spelling	oai:doaj.org-article:b6a62a8ee06f40d49a62f7a988887e552021-12-02T01:40:49ZGrowth hormone and aging: A challenging controversy1178-1998https://doaj.org/article/b6a62a8ee06f40d49a62f7a988887e552008-12-01T00:00:00Zhttps://www.dovepress.com/growth-hormone-and-aging-a-challenging-controversy-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Andrzej BartkeGeriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related products are aggressively promoted as anti-aging therapies. Well-controlled studies of the effects of rhGH treatment in endocrinologically normal elderly subjects report some improvements in body composition and a number of undesirable side effects in sharp contrast to major benefits of GH therapy in patients with GH deficiency. Controversies surrounding the potential utility of GH in treatment of a geriatric patient are fueled by increasing evidence linking GH and cancer and by remarkably increased lifespan of GH-resistant and GH-deficient mice. Conservation of cellular signaling mechanisms that influence aging in organisms ranging from worms to mammals suggests that at least some of the results obtained in mutant mice are applicable to the human. We suggest that the normal, physiological functions of GH in promoting growth, sexual maturation and fecundity involve significant costs in  terms of aging and life expectancy. Natural decline in GH levels during aging likely contributes to concomitant alterations in body composition and vigor but also may be offering important protection from cancer and other age-associated diseases.Keywords: growth hormone, longevity, cancer, anti-aging therapies, mutant miceAndrzej BartkeDove Medical PressarticleGrowth hormonelongevitycanceranti-aging therapiesmutant miceGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 659-665 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Growth hormone longevity cancer anti-aging therapies mutant mice Geriatrics RC952-954.6
spellingShingle	Growth hormone longevity cancer anti-aging therapies mutant mice Geriatrics RC952-954.6 Andrzej Bartke Growth hormone and aging: A challenging controversy
description	Andrzej BartkeGeriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related products are aggressively promoted as anti-aging therapies. Well-controlled studies of the effects of rhGH treatment in endocrinologically normal elderly subjects report some improvements in body composition and a number of undesirable side effects in sharp contrast to major benefits of GH therapy in patients with GH deficiency. Controversies surrounding the potential utility of GH in treatment of a geriatric patient are fueled by increasing evidence linking GH and cancer and by remarkably increased lifespan of GH-resistant and GH-deficient mice. Conservation of cellular signaling mechanisms that influence aging in organisms ranging from worms to mammals suggests that at least some of the results obtained in mutant mice are applicable to the human. We suggest that the normal, physiological functions of GH in promoting growth, sexual maturation and fecundity involve significant costs in  terms of aging and life expectancy. Natural decline in GH levels during aging likely contributes to concomitant alterations in body composition and vigor but also may be offering important protection from cancer and other age-associated diseases.Keywords: growth hormone, longevity, cancer, anti-aging therapies, mutant mice
format	article
author	Andrzej Bartke
author_facet	Andrzej Bartke
author_sort	Andrzej Bartke
title	Growth hormone and aging: A challenging controversy
title_short	Growth hormone and aging: A challenging controversy
title_full	Growth hormone and aging: A challenging controversy
title_fullStr	Growth hormone and aging: A challenging controversy
title_full_unstemmed	Growth hormone and aging: A challenging controversy
title_sort	growth hormone and aging: a challenging controversy
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b6a62a8ee06f40d49a62f7a988887e55
work_keys_str_mv	AT andrzejbartke growthhormoneandagingachallengingcontroversy
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Growth hormone and aging: A challenging controversy

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