Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats

Abstract Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40%...

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Autores principales:	Aline Maria Arlindo de Souza, Crystal A. West, Aline Rezende Ribeiro de Abreu, Amrita V. Pai, Laura Batista Tavares Mesquita, Hong Ji, Deoclécio Chianca, Rodrigo Cunha Alvim de Menezes, Kathryn Sandberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6a7cbb24424422e856dea0c107dd290
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spelling	oai:doaj.org-article:b6a7cbb24424422e856dea0c107dd2902021-12-02T15:09:02ZRole of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats10.1038/s41598-018-28593-62045-2322https://doaj.org/article/b6a7cbb24424422e856dea0c107dd2902018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28593-6https://doaj.org/toc/2045-2322Abstract Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40% of CT) diet for 14 days. In response to severe FR, BP allostasis was achieved by up-regulating circulating Ang-[1–8] by 1.3-fold through increased angiotensin converting enzyme (ACE) activity and by increasing the expression of AT1Rs 1.7-fold in mesenteric vessels. Activation of the RAS countered the depressor effect of the severe plasma volume reduction (≥30%). The RAS, however, still underperformed as evidenced by reduced pressor responses to Ang-[1–8] even though AT1Rs were still responsive to the depressor effects of an AT1R antagonist. The aldosterone (ALDO) response was also inadequate as no changes in plasma ALDO were observed after the large fall in plasma volume. These findings have implications for individuals who have experienced a period(s) of severe FR (e.g., anorexia nervosa, dieters, natural disasters) and suggests increased activity of the RAS in order to achieve allostasis contributes to the cardiovascular dysfunction associated with inadequate food intake.Aline Maria Arlindo de SouzaCrystal A. WestAline Rezende Ribeiro de AbreuAmrita V. PaiLaura Batista Tavares MesquitaHong JiDeoclécio ChiancaRodrigo Cunha Alvim de MenezesKathryn SandbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aline Maria Arlindo de Souza Crystal A. West Aline Rezende Ribeiro de Abreu Amrita V. Pai Laura Batista Tavares Mesquita Hong Ji Deoclécio Chianca Rodrigo Cunha Alvim de Menezes Kathryn Sandberg Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
description	Abstract Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40% of CT) diet for 14 days. In response to severe FR, BP allostasis was achieved by up-regulating circulating Ang-[1–8] by 1.3-fold through increased angiotensin converting enzyme (ACE) activity and by increasing the expression of AT1Rs 1.7-fold in mesenteric vessels. Activation of the RAS countered the depressor effect of the severe plasma volume reduction (≥30%). The RAS, however, still underperformed as evidenced by reduced pressor responses to Ang-[1–8] even though AT1Rs were still responsive to the depressor effects of an AT1R antagonist. The aldosterone (ALDO) response was also inadequate as no changes in plasma ALDO were observed after the large fall in plasma volume. These findings have implications for individuals who have experienced a period(s) of severe FR (e.g., anorexia nervosa, dieters, natural disasters) and suggests increased activity of the RAS in order to achieve allostasis contributes to the cardiovascular dysfunction associated with inadequate food intake.
format	article
author	Aline Maria Arlindo de Souza Crystal A. West Aline Rezende Ribeiro de Abreu Amrita V. Pai Laura Batista Tavares Mesquita Hong Ji Deoclécio Chianca Rodrigo Cunha Alvim de Menezes Kathryn Sandberg
author_facet	Aline Maria Arlindo de Souza Crystal A. West Aline Rezende Ribeiro de Abreu Amrita V. Pai Laura Batista Tavares Mesquita Hong Ji Deoclécio Chianca Rodrigo Cunha Alvim de Menezes Kathryn Sandberg
author_sort	Aline Maria Arlindo de Souza
title	Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
title_short	Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
title_full	Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
title_fullStr	Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
title_full_unstemmed	Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
title_sort	role of the renin angiotensin system in blood pressure allostasis-induced by severe food restriction in female fischer rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6a7cbb24424422e856dea0c107dd290
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Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats

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