Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition

Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction between GA and SIRT3. Therefore, in the present study, we showed that GA could significantly decrease SIRT3 protein levels in SW620 a...

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Autores principales:	Zhenkui Zuo, Lulu He, Xiaoyu Duan, Zining Peng, Jiarui Han
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	glycyrrhizic acid colorectal cancer anticancer sirt3 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/b6a9a0cadc3c4c79b1864d792e0451bf
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spelling	oai:doaj.org-article:b6a9a0cadc3c4c79b1864d792e0451bf2021-11-11T14:23:43ZGlycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition2165-59792165-598710.1080/21655979.2021.2001925https://doaj.org/article/b6a9a0cadc3c4c79b1864d792e0451bf2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2001925https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction between GA and SIRT3. Therefore, in the present study, we showed that GA could significantly decrease SIRT3 protein levels in SW620 and HT29 cells in a dose-dependent manner. Then, we overexpressed SIRT3 by lentivirus infection on SW620 and HT29 cells. We found that, in vitro, GA treatment significantly decreased cell viability, cell clone number, and invasion and migration number, besides significantly increasing apoptosis. Also, GA treatment significantly decreased the Bax/Bcl2 protein ratio and the expression of Cyclin D1, CDK2, CDK4, MMP-9, N-cadherin, and vimentin in SW620 and HT29 cells. Meanwhile, the SIRT3 overexpression could significantly reverse these changes. Moreover, the GA treatment could significantly decrease the weight of xenograft tumor tissues and its SIRT3 protein levels in vivo, while SIRT3 overexpression reversed these effects. Overall, GA inhibited the proliferation, invasion, and migration of colorectal cancer cells, and induced their apoptosis by SIRT3 inhibition.Zhenkui ZuoLulu HeXiaoyu DuanZining PengJiarui HanTaylor & Francis Grouparticleglycyrrhizic acidcolorectal canceranticancersirt3BiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycyrrhizic acid colorectal cancer anticancer sirt3 Biotechnology TP248.13-248.65
spellingShingle	glycyrrhizic acid colorectal cancer anticancer sirt3 Biotechnology TP248.13-248.65 Zhenkui Zuo Lulu He Xiaoyu Duan Zining Peng Jiarui Han Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
description	Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction between GA and SIRT3. Therefore, in the present study, we showed that GA could significantly decrease SIRT3 protein levels in SW620 and HT29 cells in a dose-dependent manner. Then, we overexpressed SIRT3 by lentivirus infection on SW620 and HT29 cells. We found that, in vitro, GA treatment significantly decreased cell viability, cell clone number, and invasion and migration number, besides significantly increasing apoptosis. Also, GA treatment significantly decreased the Bax/Bcl2 protein ratio and the expression of Cyclin D1, CDK2, CDK4, MMP-9, N-cadherin, and vimentin in SW620 and HT29 cells. Meanwhile, the SIRT3 overexpression could significantly reverse these changes. Moreover, the GA treatment could significantly decrease the weight of xenograft tumor tissues and its SIRT3 protein levels in vivo, while SIRT3 overexpression reversed these effects. Overall, GA inhibited the proliferation, invasion, and migration of colorectal cancer cells, and induced their apoptosis by SIRT3 inhibition.
format	article
author	Zhenkui Zuo Lulu He Xiaoyu Duan Zining Peng Jiarui Han
author_facet	Zhenkui Zuo Lulu He Xiaoyu Duan Zining Peng Jiarui Han
author_sort	Zhenkui Zuo
title	Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
title_short	Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
title_full	Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
title_fullStr	Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
title_full_unstemmed	Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
title_sort	glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via sirt3 inhibition
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/b6a9a0cadc3c4c79b1864d792e0451bf
work_keys_str_mv	AT zhenkuizuo glycyrrhizicacidexhibitsstronganticanceractivityincolorectalcancercellsviasirt3inhibition AT luluhe glycyrrhizicacidexhibitsstronganticanceractivityincolorectalcancercellsviasirt3inhibition AT xiaoyuduan glycyrrhizicacidexhibitsstronganticanceractivityincolorectalcancercellsviasirt3inhibition AT ziningpeng glycyrrhizicacidexhibitsstronganticanceractivityincolorectalcancercellsviasirt3inhibition AT jiaruihan glycyrrhizicacidexhibitsstronganticanceractivityincolorectalcancercellsviasirt3inhibition
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Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition

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