The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
Tissue-specific differences in protein folding capacities are poorly understood. Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tissue-specific phenotypes.
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Nature Portfolio
2021
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oai:doaj.org-article:b6aba57ae59741e89406ba11b3f77eab2021-12-02T14:30:28ZThe landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones10.1038/s41467-021-22369-92041-1723https://doaj.org/article/b6aba57ae59741e89406ba11b3f77eab2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22369-9https://doaj.org/toc/2041-1723Tissue-specific differences in protein folding capacities are poorly understood. Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tissue-specific phenotypes.Netta ShemeshJuman JubranShiran DrorEyal SimonovskyOmer BashaChanan ArgovIdan HekselmanMehtap Abu-QarnEkaterina VinogradovOmry MauerTatiana TiagoSerena CarraAnat Ben-ZviEsti Yeger-LotemNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Netta Shemesh Juman Jubran Shiran Dror Eyal Simonovsky Omer Basha Chanan Argov Idan Hekselman Mehtap Abu-Qarn Ekaterina Vinogradov Omry Mauer Tatiana Tiago Serena Carra Anat Ben-Zvi Esti Yeger-Lotem The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| description |
Tissue-specific differences in protein folding capacities are poorly understood. Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tissue-specific phenotypes. |
| format |
article |
| author |
Netta Shemesh Juman Jubran Shiran Dror Eyal Simonovsky Omer Basha Chanan Argov Idan Hekselman Mehtap Abu-Qarn Ekaterina Vinogradov Omry Mauer Tatiana Tiago Serena Carra Anat Ben-Zvi Esti Yeger-Lotem |
| author_facet |
Netta Shemesh Juman Jubran Shiran Dror Eyal Simonovsky Omer Basha Chanan Argov Idan Hekselman Mehtap Abu-Qarn Ekaterina Vinogradov Omry Mauer Tatiana Tiago Serena Carra Anat Ben-Zvi Esti Yeger-Lotem |
| author_sort |
Netta Shemesh |
| title |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| title_short |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| title_full |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| title_fullStr |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| title_full_unstemmed |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| title_sort |
landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b6aba57ae59741e89406ba11b3f77eab |
| work_keys_str_mv |
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