Potential clinical applications of quantum dots

Igor L Medintz1, Hedi Mattoussi2, Aaron R Clapp31Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA; 2Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, DC, USA; 3Department of Chemical and Biological Engineerin...

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Autores principales:	Igor L Medintz, Hedi Mattoussi, Aaron R Clapp
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b6addc914bb940899f105af7685991f3
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spelling	oai:doaj.org-article:b6addc914bb940899f105af7685991f32021-12-02T11:10:53ZPotential clinical applications of quantum dots1176-91141178-2013https://doaj.org/article/b6addc914bb940899f105af7685991f32008-06-01T00:00:00Zhttp://www.dovepress.com/potential-clinical-applications-of-quantum-dots-a1837https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Igor L Medintz1, Hedi Mattoussi2, Aaron R Clapp31Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA; 2Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, DC, USA; 3Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USAAbstract: The use of luminescent colloidal quantum dots in biological investigations has increased dramatically over the past several years due to their unique size-dependent optical properties and recent advances in biofunctionalization. In this review, we describe the methods for generating high-quality nanocrystals and report on current and potential uses of these versatile materials. Numerous examples are provided in several key areas including cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting.Keywords: quantum dot, nanoparticle, biosensor, fluorescence, imaging, immunoassay, toxicity, FRET Igor L MedintzHedi MattoussiAaron R ClappDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 2, Pp 151-167 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Igor L Medintz Hedi Mattoussi Aaron R Clapp Potential clinical applications of quantum dots
description	Igor L Medintz1, Hedi Mattoussi2, Aaron R Clapp31Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA; 2Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, DC, USA; 3Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, USAAbstract: The use of luminescent colloidal quantum dots in biological investigations has increased dramatically over the past several years due to their unique size-dependent optical properties and recent advances in biofunctionalization. In this review, we describe the methods for generating high-quality nanocrystals and report on current and potential uses of these versatile materials. Numerous examples are provided in several key areas including cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting.Keywords: quantum dot, nanoparticle, biosensor, fluorescence, imaging, immunoassay, toxicity, FRET
format	article
author	Igor L Medintz Hedi Mattoussi Aaron R Clapp
author_facet	Igor L Medintz Hedi Mattoussi Aaron R Clapp
author_sort	Igor L Medintz
title	Potential clinical applications of quantum dots
title_short	Potential clinical applications of quantum dots
title_full	Potential clinical applications of quantum dots
title_fullStr	Potential clinical applications of quantum dots
title_full_unstemmed	Potential clinical applications of quantum dots
title_sort	potential clinical applications of quantum dots
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b6addc914bb940899f105af7685991f3
work_keys_str_mv	AT igorlmedintz potentialclinicalapplicationsofquantumdots AT hedimattoussi potentialclinicalapplicationsofquantumdots AT aaronrclapp potentialclinicalapplicationsofquantumdots
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Potential clinical applications of quantum dots

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