FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS

Abstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating im...

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Autores principales:	G. A. Mavziutova, R. M. Fazlyeva, E. B. Tiurina, R. M. Khairullina, N. R. Bikmetova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	community-acquired pneumonia immunity cytokines il-2 il-4 il-6 il-8 tnfalpha Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b6adfbb9e51a4b5ea9cbf8a6514d337a
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spelling	oai:doaj.org-article:b6adfbb9e51a4b5ea9cbf8a6514d337a2021-11-18T08:03:39ZFEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS1563-06252313-741X10.15789/1563-0625-2007-6-605-612https://doaj.org/article/b6adfbb9e51a4b5ea9cbf8a6514d337a2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/247https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating immune complexes, phagocytic activities of peripheral neutrophils, studies of cytokines (IL-2, IL-4, IL-6, IL-8, TNFalpha) in the course of disease. Abnormalities of immune response were found that determined the severity of pneumonia and extent of inflammatory lung affection. Insufficiency of phagocytic protection and abnormality of immune complex elimination, reduced activity of effector T cells, with underlying increased reaction of NK cells, deficiency of humoral immunity factors, as reduced B-lymphocyte levels, as well as a trend to decrease in in IgM and IgG levels, may, in sum, determine a severe clinical course, along with lobular affection of lungs in community-acquired pneumonia. Imbalance of cytokines, with predominant proinflammatory activity and reduced regulatory functions may represent a significant reason of these immune disturbances, thus justifying a need for development of immunomodulatory therapy.G. A. MavziutovaR. M. FazlyevaE. B. TiurinaR. M. KhairullinaN. R. BikmetovaSPb RAACIarticlecommunity-acquired pneumoniaimmunitycytokinesil-2il-4il-6il-8tnfalphaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 6, Pp 605-612 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	community-acquired pneumonia immunity cytokines il-2 il-4 il-6 il-8 tnfalpha Immunologic diseases. Allergy RC581-607
spellingShingle	community-acquired pneumonia immunity cytokines il-2 il-4 il-6 il-8 tnfalpha Immunologic diseases. Allergy RC581-607 G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
description	Abstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating immune complexes, phagocytic activities of peripheral neutrophils, studies of cytokines (IL-2, IL-4, IL-6, IL-8, TNFalpha) in the course of disease. Abnormalities of immune response were found that determined the severity of pneumonia and extent of inflammatory lung affection. Insufficiency of phagocytic protection and abnormality of immune complex elimination, reduced activity of effector T cells, with underlying increased reaction of NK cells, deficiency of humoral immunity factors, as reduced B-lymphocyte levels, as well as a trend to decrease in in IgM and IgG levels, may, in sum, determine a severe clinical course, along with lobular affection of lungs in community-acquired pneumonia. Imbalance of cytokines, with predominant proinflammatory activity and reduced regulatory functions may represent a significant reason of these immune disturbances, thus justifying a need for development of immunomodulatory therapy.
format	article
author	G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova
author_facet	G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova
author_sort	G. A. Mavziutova
title	FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
title_short	FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
title_full	FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
title_fullStr	FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
title_full_unstemmed	FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
title_sort	features of immune disturbances in community-acquired pneumonias
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b6adfbb9e51a4b5ea9cbf8a6514d337a
work_keys_str_mv	AT gamavziutova featuresofimmunedisturbancesincommunityacquiredpneumonias AT rmfazlyeva featuresofimmunedisturbancesincommunityacquiredpneumonias AT ebtiurina featuresofimmunedisturbancesincommunityacquiredpneumonias AT rmkhairullina featuresofimmunedisturbancesincommunityacquiredpneumonias AT nrbikmetova featuresofimmunedisturbancesincommunityacquiredpneumonias
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FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS

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