Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.

<h4>Background</h4>Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is assoc...

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Autores principales: Patrick A M Jansen, Diana Rodijk-Olthuis, Edward J Hollox, Marijke Kamsteeg, Geuranne S Tjabringa, Gys J de Jongh, Ivonne M J J van Vlijmen-Willems, Judith G M Bergboer, Michelle M van Rossum, Elke M G J de Jong, Martin den Heijer, Andrea W M Evers, Mieke Bergers, John A L Armour, Patrick L J M Zeeuwen, Joost Schalkwijk
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b6b1e9ff82104ec2b1aca2b327370234
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