FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

Abstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and pecu...

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Autor principal:	T. V. Saprina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmune thyroiditis graves disease il-2 il-4 lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b6b2b405d6fe4b9fa19d380188638833
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spelling	oai:doaj.org-article:b6b2b405d6fe4b9fa19d3801886388332021-11-18T08:03:41ZFEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS1563-06252313-741X10.15789/1563-0625-2012-4-5-365-372https://doaj.org/article/b6b2b405d6fe4b9fa19d3801886388332014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/523https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and peculiarities of the immune state deviations in these clinical disorders. We evaluated interrelations between some indexes of IL-2 and IL-4 production/reception, and functional parameters of thyroid gland in the patients. Multi-directional effects of interleukin-2 upon thyroid function were revealed, e.g., reduced cell proliferation levels and decreased functional activity of thyrocytes in autoimmune Hashimoto’s thyroiditis, as well as stimulation of proliferation and hormone production by thyrocytes in Graves’ disease.T. V. SaprinaSPb RAACIarticleautoimmune thyroiditisgraves diseaseil-2il-4lymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 365-372 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmune thyroiditis graves disease il-2 il-4 lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune thyroiditis graves disease il-2 il-4 lymphocytes Immunologic diseases. Allergy RC581-607 T. V. Saprina FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
description	Abstract. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes. We have revealed some relationships and peculiarities of the immune state deviations in these clinical disorders. We evaluated interrelations between some indexes of IL-2 and IL-4 production/reception, and functional parameters of thyroid gland in the patients. Multi-directional effects of interleukin-2 upon thyroid function were revealed, e.g., reduced cell proliferation levels and decreased functional activity of thyrocytes in autoimmune Hashimoto’s thyroiditis, as well as stimulation of proliferation and hormone production by thyrocytes in Graves’ disease.
format	article
author	T. V. Saprina
author_facet	T. V. Saprina
author_sort	T. V. Saprina
title	FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_short	FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_full	FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_fullStr	FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_full_unstemmed	FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS
title_sort	features of interleukin-2 and interleukin-4 production and reception in autoimmune thyroid disorders
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b6b2b405d6fe4b9fa19d380188638833
work_keys_str_mv	AT tvsaprina featuresofinterleukin2andinterleukin4productionandreceptioninautoimmunethyroiddisorders
_version_	1718422501435899904

FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

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