Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment

Kengo Shimoda, Mahito Kimura Nippon Medical School Department of Psychiatry, Nippon Medical School, Chiba Hokusou Hospital, Chiba, Japan Abstract: Many emotional disturbances such as post-stroke depression (PSD) and emotional incontinence (EI) commonly occur following cerebrovascular events. The...

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Autores principales:	Shimoda K, Kimura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b6b5c149f6d04b5082489a112527ccd7
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spelling	oai:doaj.org-article:b6b5c149f6d04b5082489a112527ccd72021-12-02T02:08:08ZTwo cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment1178-2021https://doaj.org/article/b6b5c149f6d04b5082489a112527ccd72014-05-01T00:00:00Zhttp://www.dovepress.com/two-cases-of-emotional-disorder-after-middle-cerebral-artery-infarctio-a16990https://doaj.org/toc/1178-2021 Kengo Shimoda, Mahito Kimura Nippon Medical School Department of Psychiatry, Nippon Medical School, Chiba Hokusou Hospital, Chiba, Japan Abstract: Many emotional disturbances such as post-stroke depression (PSD) and emotional incontinence (EI) commonly occur following cerebrovascular events. The efficacy of antidepressants for these conditions has been established but their comorbid treatment has not been well characterized. In the current study, the authors describe two cases of post-stroke emotional dysregulation; one case with EI; and the other with EI complicated by PSD. The authors describe their differential responses to treatment. Case 1 developed EI after an infarct due to occlusion of the penetrating branches of the left middle cerebral artery (MCA). Case 2 developed both PSD and EI after right MCA stem occlusion. Both patients were initially treated with the selective serotonin reuptake inhibitor (SSRI) paroxetine. Case 1 reacted promptly to SSRI treatment. However, Case 2 had only a partial response to paroxetine, even after many months of treatment. Adjunctive therapy with low-dose aripiprazole was eventually added, resulting in complete improvement of both EI and PSD after 2 additional months of treatment. Thus, Case 2 required a different treatment strategy than Case 1. These findings suggest that aripiprazole adjunctive therapy could be effective for some complex post-stroke emotional disorders. Keywords: post-stroke disorder, post-stroke depression, emotional incontinence, antidepressants, aripiprazole adjunctive therapyShimoda KKimura MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 965-970 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shimoda K Kimura M Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
description	Kengo Shimoda, Mahito Kimura Nippon Medical School Department of Psychiatry, Nippon Medical School, Chiba Hokusou Hospital, Chiba, Japan Abstract: Many emotional disturbances such as post-stroke depression (PSD) and emotional incontinence (EI) commonly occur following cerebrovascular events. The efficacy of antidepressants for these conditions has been established but their comorbid treatment has not been well characterized. In the current study, the authors describe two cases of post-stroke emotional dysregulation; one case with EI; and the other with EI complicated by PSD. The authors describe their differential responses to treatment. Case 1 developed EI after an infarct due to occlusion of the penetrating branches of the left middle cerebral artery (MCA). Case 2 developed both PSD and EI after right MCA stem occlusion. Both patients were initially treated with the selective serotonin reuptake inhibitor (SSRI) paroxetine. Case 1 reacted promptly to SSRI treatment. However, Case 2 had only a partial response to paroxetine, even after many months of treatment. Adjunctive therapy with low-dose aripiprazole was eventually added, resulting in complete improvement of both EI and PSD after 2 additional months of treatment. Thus, Case 2 required a different treatment strategy than Case 1. These findings suggest that aripiprazole adjunctive therapy could be effective for some complex post-stroke emotional disorders. Keywords: post-stroke disorder, post-stroke depression, emotional incontinence, antidepressants, aripiprazole adjunctive therapy
format	article
author	Shimoda K Kimura M
author_facet	Shimoda K Kimura M
author_sort	Shimoda K
title	Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
title_short	Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
title_full	Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
title_fullStr	Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
title_full_unstemmed	Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
title_sort	two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b6b5c149f6d04b5082489a112527ccd7
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_version_	1718402672758882304

Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment

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