RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines triggers RIP1 autophosphorylation, which promotes f...

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Autores principales:	Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu, Jiahuai Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6b6ee1e3fe44299866d7ced81989a55
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spelling	oai:doaj.org-article:b6b6ee1e3fe44299866d7ced81989a552021-12-02T14:42:26ZRIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome10.1038/ncomms143292041-1723https://doaj.org/article/b6b6ee1e3fe44299866d7ced81989a552017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14329https://doaj.org/toc/2041-1723Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines triggers RIP1 autophosphorylation, which promotes functional necrosome formation.Yingying ZhangSheng Sean SuShubo ZhaoZhentao YangChuan-Qi ZhongXin ChenQixu CaiZhang-Hua YangDeli HuangRui WuJiahuai HanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingying Zhang Sheng Sean Su Shubo Zhao Zhentao Yang Chuan-Qi Zhong Xin Chen Qixu Cai Zhang-Hua Yang Deli Huang Rui Wu Jiahuai Han RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
description	Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines triggers RIP1 autophosphorylation, which promotes functional necrosome formation.
format	article
author	Yingying Zhang Sheng Sean Su Shubo Zhao Zhentao Yang Chuan-Qi Zhong Xin Chen Qixu Cai Zhang-Hua Yang Deli Huang Rui Wu Jiahuai Han
author_facet	Yingying Zhang Sheng Sean Su Shubo Zhao Zhentao Yang Chuan-Qi Zhong Xin Chen Qixu Cai Zhang-Hua Yang Deli Huang Rui Wu Jiahuai Han
author_sort	Yingying Zhang
title	RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
title_short	RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
title_full	RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
title_fullStr	RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
title_full_unstemmed	RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
title_sort	rip1 autophosphorylation is promoted by mitochondrial ros and is essential for rip3 recruitment into necrosome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b6b6ee1e3fe44299866d7ced81989a55
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RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

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