Orexin modulates behavioral fear expression through the locus coeruleus

Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons a...

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Autores principales:	Shingo Soya, Tohru M. Takahashi, Thomas J. McHugh, Takashi Maejima, Stefan Herlitze, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6b7b0ef9da64f028089ee1720edac0e
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spelling	oai:doaj.org-article:b6b7b0ef9da64f028089ee1720edac0e2021-12-02T14:40:24ZOrexin modulates behavioral fear expression through the locus coeruleus10.1038/s41467-017-01782-z2041-1723https://doaj.org/article/b6b7b0ef9da64f028089ee1720edac0e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01782-zhttps://doaj.org/toc/2041-1723Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons and enhance fear expression and generalization.Shingo SoyaTohru M. TakahashiThomas J. McHughTakashi MaejimaStefan HerlitzeManabu AbeKenji SakimuraTakeshi SakuraiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shingo Soya Tohru M. Takahashi Thomas J. McHugh Takashi Maejima Stefan Herlitze Manabu Abe Kenji Sakimura Takeshi Sakurai Orexin modulates behavioral fear expression through the locus coeruleus
description	Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons and enhance fear expression and generalization.
format	article
author	Shingo Soya Tohru M. Takahashi Thomas J. McHugh Takashi Maejima Stefan Herlitze Manabu Abe Kenji Sakimura Takeshi Sakurai
author_facet	Shingo Soya Tohru M. Takahashi Thomas J. McHugh Takashi Maejima Stefan Herlitze Manabu Abe Kenji Sakimura Takeshi Sakurai
author_sort	Shingo Soya
title	Orexin modulates behavioral fear expression through the locus coeruleus
title_short	Orexin modulates behavioral fear expression through the locus coeruleus
title_full	Orexin modulates behavioral fear expression through the locus coeruleus
title_fullStr	Orexin modulates behavioral fear expression through the locus coeruleus
title_full_unstemmed	Orexin modulates behavioral fear expression through the locus coeruleus
title_sort	orexin modulates behavioral fear expression through the locus coeruleus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b6b7b0ef9da64f028089ee1720edac0e
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Orexin modulates behavioral fear expression through the locus coeruleus

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