Two types of functionally distinct Ca2+ stores in hippocampal neurons
It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 pyramidal neurons by showing that refilling of I...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b6b7c12a9b294ae6afc7fbfb980b4c83 |
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| Sumario: | It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 pyramidal neurons by showing that refilling of IP3-sensitive stores relies on Orai2 channels, whereas Ry-sensitive stores involve VGCCs for spontaneous store refilling |
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