Two types of functionally distinct Ca2+ stores in hippocampal neurons

It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 pyramidal neurons by showing that refilling of I...

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Autores principales:	Hsing-Jung Chen-Engerer, Jana Hartmann, Rosa Maria Karl, Jun Yang, Stefan Feske, Arthur Konnerth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6b7c12a9b294ae6afc7fbfb980b4c83
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spelling	oai:doaj.org-article:b6b7c12a9b294ae6afc7fbfb980b4c832021-12-02T15:35:15ZTwo types of functionally distinct Ca2+ stores in hippocampal neurons10.1038/s41467-019-11207-82041-1723https://doaj.org/article/b6b7c12a9b294ae6afc7fbfb980b4c832019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11207-8https://doaj.org/toc/2041-1723It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 pyramidal neurons by showing that refilling of IP3-sensitive stores relies on Orai2 channels, whereas Ry-sensitive stores involve VGCCs for spontaneous store refillingHsing-Jung Chen-EngererJana HartmannRosa Maria KarlJun YangStefan FeskeArthur KonnerthNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hsing-Jung Chen-Engerer Jana Hartmann Rosa Maria Karl Jun Yang Stefan Feske Arthur Konnerth Two types of functionally distinct Ca2+ stores in hippocampal neurons
description	It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 pyramidal neurons by showing that refilling of IP3-sensitive stores relies on Orai2 channels, whereas Ry-sensitive stores involve VGCCs for spontaneous store refilling
format	article
author	Hsing-Jung Chen-Engerer Jana Hartmann Rosa Maria Karl Jun Yang Stefan Feske Arthur Konnerth
author_facet	Hsing-Jung Chen-Engerer Jana Hartmann Rosa Maria Karl Jun Yang Stefan Feske Arthur Konnerth
author_sort	Hsing-Jung Chen-Engerer
title	Two types of functionally distinct Ca2+ stores in hippocampal neurons
title_short	Two types of functionally distinct Ca2+ stores in hippocampal neurons
title_full	Two types of functionally distinct Ca2+ stores in hippocampal neurons
title_fullStr	Two types of functionally distinct Ca2+ stores in hippocampal neurons
title_full_unstemmed	Two types of functionally distinct Ca2+ stores in hippocampal neurons
title_sort	two types of functionally distinct ca2+ stores in hippocampal neurons
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b6b7c12a9b294ae6afc7fbfb980b4c83
work_keys_str_mv	AT hsingjungchenengerer twotypesoffunctionallydistinctca2storesinhippocampalneurons AT janahartmann twotypesoffunctionallydistinctca2storesinhippocampalneurons AT rosamariakarl twotypesoffunctionallydistinctca2storesinhippocampalneurons AT junyang twotypesoffunctionallydistinctca2storesinhippocampalneurons AT stefanfeske twotypesoffunctionallydistinctca2storesinhippocampalneurons AT arthurkonnerth twotypesoffunctionallydistinctca2storesinhippocampalneurons
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Two types of functionally distinct Ca2+ stores in hippocampal neurons

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