Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice

Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affective and cognitive behaviors in NCS1 knockou...

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Autores principales:	Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
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spelling	oai:doaj.org-article:b6b8f1fb46154bcdb198d9beb1bac5782021-12-02T14:16:34ZComprehensive somatosensory and neurological phenotyping of NCS1 knockout mice10.1038/s41598-021-81650-52045-2322https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac5782021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81650-5https://doaj.org/toc/2045-2322Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affective and cognitive behaviors in NCS1 knockout (KO) mice, but little is known about the physiological and pathological states associated with the loss of NCS1 in the peripheral nervous system. We previously reported that NCS1 expression was reduced following paclitaxel-induced peripheral neuropathy. Here, we comprehensively investigated the phenotypes of NCS1-KO mice through a battery of behavioral tests examining both central and peripheral nervous systems. Generally, only mild differences were observed in thermal sensation and memory acquisition between NCS1-WT and -KO male mice, but not in female mice. No differences were observed in motor performance, affective behaviors, and hearing in both sexes. These results suggest that NCS1 plays a modulatory role in sensory perceptions and cognition, particularly in male mice. NCS1 has been proposed as a pharmacological target for various diseases. Therefore, the sex-specific effects of NCS1 loss may be of clinical interest. As we examined a constitutive KO model, future studies focusing on various conditional KO models will further elucidate the precise physiological significance of NCS1.Lien D. NguyenLuca G. NolteWinston J. T. TanDenise GiuvelisJoseph Santos-SacchiEdward BilskyBarbara E. EhrlichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lien D. Nguyen Luca G. Nolte Winston J. T. Tan Denise Giuvelis Joseph Santos-Sacchi Edward Bilsky Barbara E. Ehrlich Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
description	Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affective and cognitive behaviors in NCS1 knockout (KO) mice, but little is known about the physiological and pathological states associated with the loss of NCS1 in the peripheral nervous system. We previously reported that NCS1 expression was reduced following paclitaxel-induced peripheral neuropathy. Here, we comprehensively investigated the phenotypes of NCS1-KO mice through a battery of behavioral tests examining both central and peripheral nervous systems. Generally, only mild differences were observed in thermal sensation and memory acquisition between NCS1-WT and -KO male mice, but not in female mice. No differences were observed in motor performance, affective behaviors, and hearing in both sexes. These results suggest that NCS1 plays a modulatory role in sensory perceptions and cognition, particularly in male mice. NCS1 has been proposed as a pharmacological target for various diseases. Therefore, the sex-specific effects of NCS1 loss may be of clinical interest. As we examined a constitutive KO model, future studies focusing on various conditional KO models will further elucidate the precise physiological significance of NCS1.
format	article
author	Lien D. Nguyen Luca G. Nolte Winston J. T. Tan Denise Giuvelis Joseph Santos-Sacchi Edward Bilsky Barbara E. Ehrlich
author_facet	Lien D. Nguyen Luca G. Nolte Winston J. T. Tan Denise Giuvelis Joseph Santos-Sacchi Edward Bilsky Barbara E. Ehrlich
author_sort	Lien D. Nguyen
title	Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
title_short	Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
title_full	Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
title_fullStr	Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
title_full_unstemmed	Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
title_sort	comprehensive somatosensory and neurological phenotyping of ncs1 knockout mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
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Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice

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