Serum lipid profiles and post-stroke depression in acute ischemic stroke patients

Huiping Shen,1,2,* Xinjie Tu,1,* Xiaoqian Luan,1 Yaying Zeng,1,2 Jincai He,1 Wenjie Tang21Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of China; 2First School of Clinical Medicie, Wenzhou Medical University, Wenzhou...

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Autores principales:	Shen H, Tu X, Luan X, Zeng Y, He J, Tang W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Lipid profiles high-density lipoprotein cholesterol LDL/HDL ratio post-stroke depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b6b96a5b6f9e4f2e8f1f3370173ad5a5
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spelling	oai:doaj.org-article:b6b96a5b6f9e4f2e8f1f3370173ad5a52021-12-02T01:50:25ZSerum lipid profiles and post-stroke depression in acute ischemic stroke patients1178-2021https://doaj.org/article/b6b96a5b6f9e4f2e8f1f3370173ad5a52019-06-01T00:00:00Zhttps://www.dovepress.com/serum-lipid-profiles-and-post-stroke-depression-in-acute-ischemic-stro-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Huiping Shen,1,2,* Xinjie Tu,1,* Xiaoqian Luan,1 Yaying Zeng,1,2 Jincai He,1 Wenjie Tang21Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of China; 2First School of Clinical Medicie, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China*These authors contributed equally to this work Purpose: Post-stroke depression (PSD) is a psychiatric complication after stroke that leads to poorer stroke outcomes. Recent observational studies have indicated that lipid profiles were associated with a higher risk of stroke and depression. This study aims to further explore the possible relationship between serum lipid profiles and the development of PSD.Methods: A total of 373 acute ischemic stroke patients were examined. Serum lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were measured within 24 hrs of admission. Depression symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17) at the one-month follow-up, and HAMD scores ≥7 indicated a diagnosis of PSD.Results: A total of 114 patients were diagnosed with PSD at the one-month follow-up, for a percentage of 30.6%. There were significant differences in HDL-C levels (P<0.001), LDL-C levels (P=0.002) and the LDL/HDL ratio (P<0.001) between the PSD and non-PSD groups, but no differences were observed in TGs, TC, Apo A1 or Apo B. Low serum HDL-C levels (r = −0.157, P<0.001) and elevated LDL-C levels (r =0.139, P=0.002) and the LDL/HDL ratio (r =0.227, P<0.001) were associated with HAMD scores. After adjusting for the NIHSS score, BI score, mRS score and alcohol consumption in the logistic analysis, low HDL-C levels and the highest quartile (≥3.07) of the LDL/HDL ratio were independently associated with the development of PSD (OR =0.250, 95% CI, 0.077–0.813, P=0.021 and OR =1.874, 95% CI, 1.050–3.347, P=0.034, respectively).Conclusion: Decreased levels of HDL-C and elevated levels of LDL/HDL ratio are associated with PSD. HDL-C and the LDL/HDL ratio are independent predictors of PSD.Keywords: lipid profiles, high-density lipoprotein cholesterol, LDL/HDL ratio, post-stroke depression  Shen HTu XLuan XZeng YHe JTang WDove Medical PressarticleLipid profileshigh-density lipoprotein cholesterolLDL/HDL ratiopost-stroke depressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1573-1583 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lipid profiles high-density lipoprotein cholesterol LDL/HDL ratio post-stroke depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Lipid profiles high-density lipoprotein cholesterol LDL/HDL ratio post-stroke depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shen H Tu X Luan X Zeng Y He J Tang W Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
description	Huiping Shen,1,2,* Xinjie Tu,1,* Xiaoqian Luan,1 Yaying Zeng,1,2 Jincai He,1 Wenjie Tang21Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of China; 2First School of Clinical Medicie, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China*These authors contributed equally to this work Purpose: Post-stroke depression (PSD) is a psychiatric complication after stroke that leads to poorer stroke outcomes. Recent observational studies have indicated that lipid profiles were associated with a higher risk of stroke and depression. This study aims to further explore the possible relationship between serum lipid profiles and the development of PSD.Methods: A total of 373 acute ischemic stroke patients were examined. Serum lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were measured within 24 hrs of admission. Depression symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17) at the one-month follow-up, and HAMD scores ≥7 indicated a diagnosis of PSD.Results: A total of 114 patients were diagnosed with PSD at the one-month follow-up, for a percentage of 30.6%. There were significant differences in HDL-C levels (P<0.001), LDL-C levels (P=0.002) and the LDL/HDL ratio (P<0.001) between the PSD and non-PSD groups, but no differences were observed in TGs, TC, Apo A1 or Apo B. Low serum HDL-C levels (r = −0.157, P<0.001) and elevated LDL-C levels (r =0.139, P=0.002) and the LDL/HDL ratio (r =0.227, P<0.001) were associated with HAMD scores. After adjusting for the NIHSS score, BI score, mRS score and alcohol consumption in the logistic analysis, low HDL-C levels and the highest quartile (≥3.07) of the LDL/HDL ratio were independently associated with the development of PSD (OR =0.250, 95% CI, 0.077–0.813, P=0.021 and OR =1.874, 95% CI, 1.050–3.347, P=0.034, respectively).Conclusion: Decreased levels of HDL-C and elevated levels of LDL/HDL ratio are associated with PSD. HDL-C and the LDL/HDL ratio are independent predictors of PSD.Keywords: lipid profiles, high-density lipoprotein cholesterol, LDL/HDL ratio, post-stroke depression
format	article
author	Shen H Tu X Luan X Zeng Y He J Tang W
author_facet	Shen H Tu X Luan X Zeng Y He J Tang W
author_sort	Shen H
title	Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
title_short	Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
title_full	Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
title_fullStr	Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
title_full_unstemmed	Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
title_sort	serum lipid profiles and post-stroke depression in acute ischemic stroke patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b6b96a5b6f9e4f2e8f1f3370173ad5a5
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Serum lipid profiles and post-stroke depression in acute ischemic stroke patients

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