Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

Tumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own production of angiogenic ligands to deplete adjacent...

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Autores principales:	Amber N. Stratman, Olivia M. Farrelly, Constantinos M. Mikelis, Mayumi F. Miller, Zhiyong Wang, Van N. Pham, Andrew E. Davis, Margaret C. Burns, Sofia A. Pezoa, Daniel Castranova, Joseph J. Yano, Tina M. Kilts, George E. Davis, J. Silvio Gutkind, Brant M. Weinstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6ba0e8777294e85b048f9e6ce5693a2
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spelling	oai:doaj.org-article:b6ba0e8777294e85b048f9e6ce5693a22021-12-02T15:34:12ZAnti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling10.1038/s41467-020-14956-z2041-1723https://doaj.org/article/b6ba0e8777294e85b048f9e6ce5693a22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14956-zhttps://doaj.org/toc/2041-1723Tumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own production of angiogenic ligands to deplete adjacent endothelial cells of the capacity to respond to these signals.Amber N. StratmanOlivia M. FarrellyConstantinos M. MikelisMayumi F. MillerZhiyong WangVan N. PhamAndrew E. DavisMargaret C. BurnsSofia A. PezoaDaniel CastranovaJoseph J. YanoTina M. KiltsGeorge E. DavisJ. Silvio GutkindBrant M. WeinsteinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amber N. Stratman Olivia M. Farrelly Constantinos M. Mikelis Mayumi F. Miller Zhiyong Wang Van N. Pham Andrew E. Davis Margaret C. Burns Sofia A. Pezoa Daniel Castranova Joseph J. Yano Tina M. Kilts George E. Davis J. Silvio Gutkind Brant M. Weinstein Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
description	Tumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own production of angiogenic ligands to deplete adjacent endothelial cells of the capacity to respond to these signals.
format	article
author	Amber N. Stratman Olivia M. Farrelly Constantinos M. Mikelis Mayumi F. Miller Zhiyong Wang Van N. Pham Andrew E. Davis Margaret C. Burns Sofia A. Pezoa Daniel Castranova Joseph J. Yano Tina M. Kilts George E. Davis J. Silvio Gutkind Brant M. Weinstein
author_facet	Amber N. Stratman Olivia M. Farrelly Constantinos M. Mikelis Mayumi F. Miller Zhiyong Wang Van N. Pham Andrew E. Davis Margaret C. Burns Sofia A. Pezoa Daniel Castranova Joseph J. Yano Tina M. Kilts George E. Davis J. Silvio Gutkind Brant M. Weinstein
author_sort	Amber N. Stratman
title	Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
title_short	Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
title_full	Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
title_fullStr	Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
title_full_unstemmed	Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
title_sort	anti-angiogenic effects of vegf stimulation on endothelium deficient in phosphoinositide recycling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6ba0e8777294e85b048f9e6ce5693a2
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Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

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