A microfluidics platform for combinatorial drug screening on cancer biopsies

A microfluidics platform for combinatorial drug screening on cancer biopsies

Cancer patients exhibit specific sensitivities toward drug combinations that cannot be easily predicted. Here the authors setup a microfluidic platform that allows testing of multiple drug combinations correctly predicting sensitivity in vivo and they use it on patients biopsies to define effective...

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Auteurs principaux: Federica Eduati, Ramesh Utharala, Dharanija Madhavan, Ulf Peter Neumann, Thomas Longerich, Thorsten Cramer, Julio Saez-Rodriguez, Christoph A. Merten
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/b6bc84e761d240379ee00dadd6ae25c4
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spelling oai:doaj.org-article:b6bc84e761d240379ee00dadd6ae25c42021-12-02T15:34:20ZA microfluidics platform for combinatorial drug screening on cancer biopsies10.1038/s41467-018-04919-w2041-1723https://doaj.org/article/b6bc84e761d240379ee00dadd6ae25c42018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04919-whttps://doaj.org/toc/2041-1723Cancer patients exhibit specific sensitivities toward drug combinations that cannot be easily predicted. Here the authors setup a microfluidic platform that allows testing of multiple drug combinations correctly predicting sensitivity in vivo and they use it on patients biopsies to define effective drugs.Federica EduatiRamesh UtharalaDharanija MadhavanUlf Peter NeumannThomas LongerichThorsten CramerJulio Saez-RodriguezChristoph A. MertenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Federica Eduati
Ramesh Utharala
Dharanija Madhavan
Ulf Peter Neumann
Thomas Longerich
Thorsten Cramer
Julio Saez-Rodriguez
Christoph A. Merten
A microfluidics platform for combinatorial drug screening on cancer biopsies
description Cancer patients exhibit specific sensitivities toward drug combinations that cannot be easily predicted. Here the authors setup a microfluidic platform that allows testing of multiple drug combinations correctly predicting sensitivity in vivo and they use it on patients biopsies to define effective drugs.
format article
author Federica Eduati
Ramesh Utharala
Dharanija Madhavan
Ulf Peter Neumann
Thomas Longerich
Thorsten Cramer
Julio Saez-Rodriguez
Christoph A. Merten
author_facet Federica Eduati
Ramesh Utharala
Dharanija Madhavan
Ulf Peter Neumann
Thomas Longerich
Thorsten Cramer
Julio Saez-Rodriguez
Christoph A. Merten
author_sort Federica Eduati
title A microfluidics platform for combinatorial drug screening on cancer biopsies
title_short A microfluidics platform for combinatorial drug screening on cancer biopsies
title_full A microfluidics platform for combinatorial drug screening on cancer biopsies
title_fullStr A microfluidics platform for combinatorial drug screening on cancer biopsies
title_full_unstemmed A microfluidics platform for combinatorial drug screening on cancer biopsies
title_sort microfluidics platform for combinatorial drug screening on cancer biopsies
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b6bc84e761d240379ee00dadd6ae25c4
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