An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase. They find that upon binding to the reductase, the catalytic domain of cytochrome P450 1A1 reorients subject to the constraints of membran...

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Autores principales:	Goutam Mukherjee, Prajwal P. Nandekar, Rebecca C. Wade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b6c55376663c4ca48528fe879b9a75a4
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spelling	oai:doaj.org-article:b6c55376663c4ca48528fe879b9a75a42021-12-02T15:07:32ZAn electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase10.1038/s42003-020-01568-y2399-3642https://doaj.org/article/b6c55376663c4ca48528fe879b9a75a42021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01568-yhttps://doaj.org/toc/2399-3642Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase. They find that upon binding to the reductase, the catalytic domain of cytochrome P450 1A1 reorients subject to the constraints of membrane binding, potentially explaining why the electron transfer rates between the proteins are low when compared to those of soluble bacterial cytochrome P450s.Goutam MukherjeePrajwal P. NandekarRebecca C. WadeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Goutam Mukherjee Prajwal P. Nandekar Rebecca C. Wade An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
description	Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase. They find that upon binding to the reductase, the catalytic domain of cytochrome P450 1A1 reorients subject to the constraints of membrane binding, potentially explaining why the electron transfer rates between the proteins are low when compared to those of soluble bacterial cytochrome P450s.
format	article
author	Goutam Mukherjee Prajwal P. Nandekar Rebecca C. Wade
author_facet	Goutam Mukherjee Prajwal P. Nandekar Rebecca C. Wade
author_sort	Goutam Mukherjee
title	An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
title_short	An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
title_full	An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
title_fullStr	An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
title_full_unstemmed	An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
title_sort	electron transfer competent structural ensemble of membrane-bound cytochrome p450 1a1 and cytochrome p450 oxidoreductase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6c55376663c4ca48528fe879b9a75a4
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An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

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