Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper

Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts...

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Autores principales:	Kok Tong WONG, Hasnah OSMAN, Thaigarajan PARUMASİVAM, Jafri Malin ABDULLAH, Mohd. Zaheen HASSAN, Mohamad Nurul Azmi MOHAMAD TAİB
Formato:	article
Lenguaje:	EN
Publicado:	Turkish Chemical Society 2021
Materias:	dendrocalamus asper antimalarial p. falciparum molecular docking dihydrofolate reductase-thymidylate synthase (dhfr-ts) Chemistry QD1-999
Acceso en línea:	https://doi.org/10.18596/jotcsa.904529 https://doaj.org/article/b6cc0f59cb7a4771a20e969e0d4e8749
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spelling	oai:doaj.org-article:b6cc0f59cb7a4771a20e969e0d4e87492021-11-20T09:25:48Z Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper https://doi.org/10.18596/jotcsa.9045292149-0120https://doaj.org/article/b6cc0f59cb7a4771a20e969e0d4e87492021-11-01T00:00:00Zhttps://dergipark.org.tr/tr/pub/jotcsa/issue/64621/904529https://doaj.org/toc/2149-0120Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts the P. falciparum strain 3D7. One new metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with the four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3), 1-methoxy-4-(methoxymethyl)benzene (4) and 4-hydroxybenzaldehyde (5) were isolated from the crude extract using chromatographic methods: MPLC, UPLC/MS, analytical and preparative HPLC. Among these, compounds 1, 3 and 4 showed promising antimalarial activity with IC50 between 0.8-2.2 μg/mL. The molecular docking between the most potent compound 3 and dihydrofolate reductase-thymidylate synthase (DHFR-TS) was done to understand and exploring ligand-receptor interactions and hypothesize the compound's refinementsKok Tong WONGHasnah OSMANThaigarajan PARUMASİVAMJafri Malin ABDULLAHMohd. Zaheen HASSANMohamad Nurul Azmi MOHAMAD TAİBTurkish Chemical Societyarticledendrocalamus asperantimalarialp. falciparummolecular dockingdihydrofolate reductase-thymidylate synthase (dhfr-ts)ChemistryQD1-999ENJournal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 4, Pp 995 -1002 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dendrocalamus asper antimalarial p. falciparum molecular docking dihydrofolate reductase-thymidylate synthase (dhfr-ts) Chemistry QD1-999
spellingShingle	dendrocalamus asper antimalarial p. falciparum molecular docking dihydrofolate reductase-thymidylate synthase (dhfr-ts) Chemistry QD1-999 Kok Tong WONG Hasnah OSMAN Thaigarajan PARUMASİVAM Jafri Malin ABDULLAH Mohd. Zaheen HASSAN Mohamad Nurul Azmi MOHAMAD TAİB Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
description	Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts the P. falciparum strain 3D7. One new metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with the four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3), 1-methoxy-4-(methoxymethyl)benzene (4) and 4-hydroxybenzaldehyde (5) were isolated from the crude extract using chromatographic methods: MPLC, UPLC/MS, analytical and preparative HPLC. Among these, compounds 1, 3 and 4 showed promising antimalarial activity with IC50 between 0.8-2.2 μg/mL. The molecular docking between the most potent compound 3 and dihydrofolate reductase-thymidylate synthase (DHFR-TS) was done to understand and exploring ligand-receptor interactions and hypothesize the compound's refinements
format	article
author	Kok Tong WONG Hasnah OSMAN Thaigarajan PARUMASİVAM Jafri Malin ABDULLAH Mohd. Zaheen HASSAN Mohamad Nurul Azmi MOHAMAD TAİB
author_facet	Kok Tong WONG Hasnah OSMAN Thaigarajan PARUMASİVAM Jafri Malin ABDULLAH Mohd. Zaheen HASSAN Mohamad Nurul Azmi MOHAMAD TAİB
author_sort	Kok Tong WONG
title	Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
title_short	Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
title_full	Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
title_fullStr	Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
title_full_unstemmed	Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
title_sort	antimalarial evaluation of the chemical constituents isolated from dendrocalamus asper
publisher	Turkish Chemical Society
publishDate	2021
url	https://doi.org/10.18596/jotcsa.904529 https://doaj.org/article/b6cc0f59cb7a4771a20e969e0d4e8749
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Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper

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